ID   VIRG_AGRRH              Reviewed;         241 AA.
AC   P13359;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 2.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Regulatory protein VirG;
GN   Name=virG;
OS   Agrobacterium rhizogenes.
OG   Plasmid pRiA4b.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium.
OX   NCBI_TaxID=359;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=A4;
RX   PubMed=2670679; DOI=10.1016/0378-1119(89)90325-9;
RA   Aoyama T., Hirayama T., Tamamoto S., Oka A.;
RT   "Putative start codon TTG for the regulatory protein VirG of the hairy-
RT   root-inducing plasmid pRiA4.";
RL   Gene 78:173-178(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 206-241.
RX   PubMed=3185501; DOI=10.1007/bf00339586;
RA   Hirayama T., Muranaka T., Ohkawa H., Oka A.;
RT   "Organization and characterization of the virCD genes from Agrobacterium
RT   rhizogenes.";
RL   Mol. Gen. Genet. 213:229-237(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-8.
RC   STRAIN=A4;
RX   PubMed=2479910; DOI=10.1093/nar/17.21.8711;
RA   Aoyama T., Takanami M., Oka A.;
RT   "Signal structure for transcriptional activation in the upstream regions of
RT   virulence genes on the hairy-root-inducing plasmid A4.";
RL   Nucleic Acids Res. 17:8711-8725(1989).
CC   -!- FUNCTION: VirG is required for the positive regulation of at least two
CC       vir loci encoded by the Ri plasmid of A.rhizogenes.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- PTM: Phosphorylated by wide host range (WHR) VirA protein.
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DR   EMBL; M26938; AAA26373.1; -; Genomic_DNA.
DR   EMBL; X12867; CAA31347.1; -; Genomic_DNA.
DR   EMBL; X15914; CAA34027.1; -; Genomic_DNA.
DR   PIR; JS0239; JS0239.
DR   AlphaFoldDB; P13359; -.
DR   SMR; P13359; -.
DR   STRING; 359.CN09_19205; -.
DR   PRIDE; P13359; -.
DR   eggNOG; COG0745; Bacteria.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Activator; Crown gall tumor; Cytoplasm; DNA-binding; Phosphoprotein;
KW   Plasmid; Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN           1..241
FT                   /note="Regulatory protein VirG"
FT                   /id="PRO_0000081264"
FT   DOMAIN          3..117
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        129..229
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         52
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   241 AA;  27256 MW;  A1B128FE3589DDD7 CRC64;
     MKHVLVIDDD VAMRHLIVEY LTIHAFKVTA VADSKQFNRV LSSETVDVAV VDLNLGREDG
     LEIVRTLATK SDVPMIIISG DRLEEADKVV ALELGATDFI AKPFGTREFL ARIRVALRER
     PSVARTKDRR SFYFADWTLN IRQRRLISEE GGEIKLTAGE FNLLVAFLEK PRDVLSREQL
     LIASRVREEE VYDRSIDVLI FRLRRKLEGD PTSPQLIKTA RGAGYFFDAD VNVSYGGMMA
     A