ID   VIRS_MYCTO              Reviewed;         340 AA.
AC   P9WMJ2; L0TBI3; O53299; Q06861;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=HTH-type transcriptional regulator VirS;
DE   AltName: Full=Virulence-regulating protein VirS;
GN   Name=virS; OrderedLocusNames=MT3167;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Regulates the expression of the mymA operon. {ECO:0000250}.
CC   -!- PTM: Phosphorylated by PknK. Phosphorylation increases affinity for the
CC       mymA promoter (By similarity). {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK47503.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE000516; AAK47503.1; ALT_INIT; Genomic_DNA.
DR   PIR; F70852; F70852.
DR   RefSeq; WP_003416068.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WMJ2; -.
DR   SMR; P9WMJ2; -.
DR   EnsemblBacteria; AAK47503; AAK47503; MT3167.
DR   KEGG; mtc:MT3167; -.
DR   PATRIC; fig|83331.31.peg.3413; -.
DR   HOGENOM; CLU_047522_1_2_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   InterPro; IPR032687; AraC-type_N.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR018060; HTH_AraC.
DR   Pfam; PF12625; Arabinose_bd; 1.
DR   Pfam; PF12833; HTH_18; 1.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Phosphoprotein; Transcription; Transcription regulation;
KW   Virulence.
FT   CHAIN           1..340
FT                   /note="HTH-type transcriptional regulator VirS"
FT                   /id="PRO_0000427294"
FT   DOMAIN          236..334
FT                   /note="HTH araC/xylS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        254..275
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
FT   DNA_BIND        301..324
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00593"
SQ   SEQUENCE   340 AA;  37789 MW;  D3EB1B640D3BEF75 CRC64;
     MELGSLIRAT NLWGYTDLMR ELGADPLPFL RRFDIPPGIE HQEDAFMSLA GFVRMLEASA
     AELDCPDFGL RLARWQGLGI LGPVAVIARN AATLFGGLEA IGRYLYVHSP ALTLTVSSTT
     ARSNVRFGYE VTEPGIPYPL QGYELSMANA ARMIRLLGGP QARARVFSFR HAQLGTDAAY
     REALGCTVRF GRTWCGFEVD HRLAGRPIDH ADPETKRIAT KYLESQYLPS DATLSERVVG
     LARRLLPTGQ CSAEAIADQL DMHPRTLQRR LAAEGLRCHD LIERERRAQA ARYLAQPGLY
     LSQIAVLLGY SEQSALNRSC RRWFGMTPRQ YRAYGGVSGR