ID   VIT1_CERCA              Reviewed;         437 AA.
AC   P27878;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Vitellogenin-1;
DE   AltName: Full=Vitellogenin I;
DE   AltName: Full=Yolk protein 1;
DE   Flags: Precursor;
GN   Name=VG1-GAMMA;
OS   Ceratitis capitata (Mediterranean fruit fly) (Tephritis capitata).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Tephritoidea;
OC   Tephritidae; Ceratitis; Ceratitis.
OX   NCBI_TaxID=7213;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Benakeion;
RX   PubMed=1903120; DOI=10.1093/genetics/127.4.769;
RA   Rina M., Savakis C.;
RT   "A cluster of vitellogenin genes in the Mediterranean fruit fly Ceratitis
RT   capitata: sequence and structural conservation in dipteran yolk proteins
RT   and their genes.";
RL   Genetics 127:769-780(1991).
CC   -!- FUNCTION: Vitellogenin is the major yolk protein of eggs where it is
CC       used as a food source during embryogenesis.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Synthesized in the fat body and ovarian follicle
CC       cells and accumulate in the oocyte.
CC   -!- INDUCTION: By beta-ecdysone; in males.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC       {ECO:0000305}.
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DR   EMBL; X54661; CAA38472.1; -; Genomic_DNA.
DR   PIR; S22889; S22889.
DR   AlphaFoldDB; P27878; -.
DR   SMR; P27878; -.
DR   ESTHER; cerca-1vite; Yolk-Protein_dipter.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013818; Lipase.
DR   InterPro; IPR000734; TAG_lipase.
DR   PANTHER; PTHR11610; PTHR11610; 1.
DR   Pfam; PF00151; Lipase; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000250"
FT   CHAIN           20..437
FT                   /note="Vitellogenin-1"
FT                   /id="PRO_0000017817"
FT   REGION          161..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          405..437
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   437 AA;  48122 MW;  473EBC925C5A6252 CRC64;
     MNPLKIFCFL ALVIAVASAN KHGKNKDNAG PNSLKPTDWL SVEELQSMTA IDDITLQQLE
     NMSVEDAERK IEKIYHLSQI NHALEPSYVP SPSNVPVMLM KPNGQSQQTN HNELVEAAKQ
     QPNFGDEEVT IFITGMPQTS SAVLKANKKL VQAYMQRYNG QQQPINGNKD YDYGSSQGNQ
     GATSSEEDYS ESWKNQKSTK GNLVIINLGS TLTNMKRFAL LDVEQTGNMI GKTLVQLTNE
     VDVPQEIIHI VAQCIGAQVA GAAGRQYKRL TGHQLRRITA LDPSKIFAKN RNALTGLARG
     DADFVDAIHT STCGMGTRQR VGDVDFYVNG PASTAPGTNN VVEASMRATR YFAESLRPGN
     ERNFPAVAAN SLNQYENNEG NGKRAYMGIA TDFDLEGDYI LKVNPKSPFG KSAPAQKQRR
     YHGLHQSWKS GKNQNQE