VIT2_PERAM
ID VIT2_PERAM Reviewed; 1876 AA.
AC Q9BPS0;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Vitellogenin-2;
DE Short=Vg-2;
DE Flags: Precursor;
GN Name=VG2;
OS Periplaneta americana (American cockroach) (Blatta americana).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Blattidae;
OC Blattinae; Periplaneta.
OX NCBI_TaxID=6978;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Fat body;
RA Tufail M., Hatakeyama M., Takeda M., Lee J.M.;
RT "Periplaneta americana vitellogenin-2 (Vg-2).";
RL Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Precursor of the egg-yolk proteins that are sources of
CC nutrients during embryonic development. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
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DR EMBL; AB047401; BAB32673.1; -; mRNA.
DR AlphaFoldDB; Q9BPS0; -.
DR SMR; Q9BPS0; -.
DR PRIDE; Q9BPS0; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.20; -; 1.
DR Gene3D; 2.30.230.10; -; 1.
DR InterPro; IPR015819; Lipid_transp_b-sht_shell.
DR InterPro; IPR011030; Lipovitellin_superhlx_dom.
DR InterPro; IPR015816; Vitellinogen_b-sht_N.
DR InterPro; IPR015255; Vitellinogen_open_b-sht.
DR InterPro; IPR001747; Vitellogenin_N.
DR InterPro; IPR001846; VWF_type-D.
DR Pfam; PF09172; DUF1943; 1.
DR Pfam; PF01347; Vitellogenin_N; 1.
DR Pfam; PF00094; VWD; 1.
DR SMART; SM01169; DUF1943; 1.
DR SMART; SM00638; LPD_N; 1.
DR SMART; SM00216; VWD; 1.
DR SUPFAM; SSF48431; SSF48431; 1.
DR SUPFAM; SSF56968; SSF56968; 2.
DR PROSITE; PS51211; VITELLOGENIN; 1.
DR PROSITE; PS51233; VWFD; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Secreted; Signal; Storage protein.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..1876
FT /note="Vitellogenin-2"
FT /id="PRO_0000041551"
FT DOMAIN 21..838
FT /note="Vitellogenin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00557"
FT DOMAIN 1518..1703
FT /note="VWFD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT REGION 322..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1192..1239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1729..1788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..384
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1196..1212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1736..1774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 211
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 290
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 409
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 595
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 631
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 932
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1012
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1055
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1318
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1398
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1417
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1424
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1469
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1532
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1636
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1719
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1760
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1770
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 1520..1664
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
SQ SEQUENCE 1876 AA; 215943 MW; 829666B17B881EFB CRC64;
MMWKTLLCCL LAVSAAALDG WEPGKRYEYH VRGRTLTALH EVANQYSGFR FKGKLVIEPH
TPSVLRGQLK DTYHMTVHRM LPDGWDQKFE ERESNWERVG MKNKPFEVHV GNEFQFNKLI
VTEDTPVWET NMIKGVLSQI QVNLKEVGPD PRDEQEDRLR KIFKVHESSV TGRCEVLYDI
TPITKFNMLP QPLVEIEEEN VNVLQVMKTQ NFTDCKKLPS YVHGFYNFHN VFPAQNKAGF
MSRSQQTRTI VSRNKETGRF TIRSSVTFHE VVLKPELFNS QQGISVSRMN VTLEEIKSQQ
HIPPPRPPKD VGDLVYRYSA ETGEPSQRDS AYALESNSDS SSSSSSSSSE ENAANSRHRS
SSSSSSSRSS EEMRDSKKHP RASTTESQPR NSRSRRSLQN SKRSINMYND SSSSSSSSSS
EEYLLPRPHI ENAPNIPFMP YFVGNQGSKI GEVDPEKIVL LARTISSELQ EPDTMVKKNI
LSRFSILTNL VRAASFSQLE EATKRLYYRV ERADNGDESK LDAWKAYRDS VAQAGTPAAL
KMVHTWIRKE YIKDEEAAKV VAVIPHAADT PTDNYIAYFF EMVKDPVVHG EKYLNSSAVL
AFSKLLRLAA VDSEAVRRYP VHVFGRMVPK NFSARVKEYI EYFANKLKNA VKDKDSHKIQ
VYTRALGNTG HADIIRHFEP YLVGRESVST HERVTMVFCL DEFVKTQPSV AQYILLRLFE
NVGETQEIRV AALYLLMKTD VSAELFQRLA EYTKFDKNHQ VVSAVQSAIR SAAKVEGPYK
KETAKNAQAA VKILSSKPYD DSYSKSFILN NYRREIDVGY SRLYNQIGSR DSFMPKSVFY
KLVNIIDGDR DDQAKFGGAV SSVRDVIDFI RQQFKKDDSQ DELENSKYAE DDDIWDLREI
ANLLEMEEEN VDPLEGNVHY DYFGAQRFFT LNKTSFEFRE ELKKYFKKPQ ITNINKLYNR
MELKVGYPNV MGVPFFFTFK RPTLVKLTAK TFIMPLKPCD HGKPHKFPRI FNVTSDVSFV
YSFDMHSHMG VVAPFNKKEY VTGIQRKHMI QIPLNVSVHV NLDKNKVAAD FKPYYEDNFK
VAEARGIPFT TVHDIKSLVP YVEAEHTSYI RVRPSKAYEG NFGKSVGMVY HYNFETDQQF
FDYKWFSSNY FLHYPNVAFY YGWEAQPVFY YDFKLYLDSH NSPAKTVQLK ASYDNRYTQP
EEEEETRQHS KIRRPRSASR KHRRSRHEER APLENLEVSD TETQREELYD IVLPAVRAGR
LYYASVSVAF KGEENVYSKY EVEGALASSQ VNEHISTMLR AHSNDAERKH QYAHVRVNVT
MPQVPVIDYR KALEFDPTSK IQCEVHFGDT PEKKSKVYFQ GKFERTDERK KFVAESDMAQ
LCSAQQNNKN YLLPACRNVT EEASKLDKYF FKVKYENLSE KCRNRTYKAY SYLRHYFFPY
ITENVYPDER KTDSVEVQVQ FNEEINAVNV SVKAPILNVE FTDVRVYNKY ARALFSLNPR
YPLLSQVAKT AFPQYYEPTC VVDYSKVNTF DNRTYEHDML NDWVEVMFHK PRSKIYKQVS
VSAKQAHSKM VLKVLRGDEV KFEMKQPRDS SSSPELKMND KVIEYERSPA FIHYKHELIA
VAYALPSKAL HLDLLNDSLV FVYDGERVML HAGNHYRNQV RGLCGTFDGE PSTDFKAPQN
CHVRDVEDLI LAYTLVRDLD RSRLRDENIC VREDVQLVNL TNHRHAEKSG IRPYDIDDDS
SSSSSSSSSS SSSSSSSKSN STSSSSSESN ESALPRGENK LHRAQQPSRN CHMHLHRIVT
HNGKQCISKL ALTECAPLCR EESHTTKTEA FVCFPPGPTA DHYTKLVRKG VSPDFSRKTD
IVNLRVTIPS RCVSKI
