ID   VITA1_XENLA             Reviewed;          71 AA.
AC   P19009;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Vitellogenin-A1;
DE            Short=VTG A1;
DE   Flags: Precursor; Fragment;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6504704; DOI=10.1093/nar/12.22.8595;
RA   Germond J.-E., Walker P., ten Heggeler B., Brown-Luedi M., de Bony E.,
RA   Wahli W.;
RT   "Evolution of vitellogenin genes: comparative analysis of the nucleotide
RT   sequences downstream of the transcription initiation site of four Xenopus
RT   laevis and one chicken gene.";
RL   Nucleic Acids Res. 12:8595-8609(1984).
CC   -!- FUNCTION: Precursor of the major egg-yolk proteins that are sources of
CC       nutrients during early development of oviparous organisms.
CC   -!- TISSUE SPECIFICITY: Produced by the liver, secreted into the blood and
CC       then sequestered by receptor mediated endocytosis into growing oocytes,
CC       where it is generally cleaved, giving rise to the respective yolk
CC       components.
CC   -!- INDUCTION: By steroids (estrogen).
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DR   EMBL; X01168; CAA25615.1; -; Genomic_DNA.
DR   PIR; A23876; A23876.
DR   AlphaFoldDB; P19009; -.
DR   SMR; P19009; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR   GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.230.10; -; 1.
DR   InterPro; IPR015819; Lipid_transp_b-sht_shell.
DR   InterPro; IPR015816; Vitellinogen_b-sht_N.
DR   InterPro; IPR001747; Vitellogenin_N.
DR   Pfam; PF01347; Vitellogenin_N; 1.
DR   SUPFAM; SSF56968; SSF56968; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome; Signal; Storage protein.
FT   SIGNAL          1..15
FT   CHAIN           16..>71
FT                   /note="Vitellogenin-A1"
FT                   /id="PRO_0000041584"
FT   DOMAIN          24..>71
FT                   /note="Vitellogenin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00557"
FT   NON_TER         71
SQ   SEQUENCE   71 AA;  7827 MW;  C45881649FF8A81A CRC64;
     MRGIILALLL AIAGSERTQI EPVFSESKTS VYNYEAVILN GFPESGLSRA GIKINCKVEI
     SAYAQRSYFL K