ID   VITF3_VACCC             Reviewed;         382 AA.
AC   P20998;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   29-SEP-2021, entry version 63.
DE   RecName: Full=Intermediate transcription factor 3 large subunit;
DE   AltName: Full=VITF-3 45 kDa subunit;
GN   Name=VITF3L; ORFNames=A23R;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: Acts with RNA polymerase to initiate transcription from
CC       intermediate gene promoters. {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimerizes with protein A8 to form the virus intermediate
CC       transcription factor (VITF)-3. {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the early phase of the viral replicative cycle.
CC   -!- SIMILARITY: Belongs to the poxviruses A23 family. {ECO:0000305}.
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DR   EMBL; M35027; AAA48147.1; -; Genomic_DNA.
DR   PIR; G42519; G42519.
DR   DIP; DIP-2183N; -.
DR   IntAct; P20998; 3.
DR   MINT; P20998; -.
DR   Proteomes; UP000008269; Genome.
DR   InterPro; IPR008789; Poxvirus_intermed-TF.
DR   Pfam; PF05718; Pox_int_trans; 1.
PE   2: Evidence at transcript level;
KW   Activator; Early protein; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..382
FT                   /note="Intermediate transcription factor 3 large subunit"
FT                   /id="PRO_0000099181"
SQ   SEQUENCE   382 AA;  44637 MW;  126FC844BB7F4BBC CRC64;
     MDNLFTFLHE IEDRYARTIF NFHLISCDEI GDIYGLMKER ISSEDMFDNI VYNKDIHHAI
     KKLVYCDIQL TKHIINQNTY PVFNDSSQVK CCHYFDINSD NSNISSRTVE IFEREKSSLV
     SYIKTTNKKR KVNYGEIKKT VHGGTNANYF SGKKSDEYLS TTVRSNINQP WIKTISKRMR
     VDIINHSIVT RGKSSILQTI EIIFTNRTCV KIFKDSTMHI ILSKDKDEKG CIHMIDKLFY
     VYYNLFLLFE DIIQNEYFKE VANVVNHVLT ATALDEKLFL IKKMAEHDVY GVSNFKIGMF
     NLTFIKSLDH TVFPSLLDED SKIKFFKGKK LNIVALRSLE DCINYVTKSE NMIEMMKERS
     TILNSIDIET ESVDRLKELL LK