ID   VITF3_VACCW             Reviewed;         382 AA.
AC   Q80HV2;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   02-JUN-2021, entry version 47.
DE   RecName: Full=Intermediate transcription factor 3 large subunit;
DE   AltName: Full=VITF-3;
GN   Name=VITF3L; OrderedLocusNames=VACWR143; ORFNames=A23R;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, AND SUBUNIT.
RX   PubMed=10077573; DOI=10.1073/pnas.96.6.2692;
RA   Sanz P., Moss B.;
RT   "Identification of a transcription factor, encoded by two vaccinia virus
RT   early genes, that regulates the intermediate stage of viral gene
RT   expression.";
RL   Proc. Natl. Acad. Sci. U.S.A. 96:2692-2697(1999).
CC   -!- FUNCTION: Acts with RNA polymerase to initiate transcription from
CC       intermediate gene promoters. {ECO:0000269|PubMed:10077573}.
CC   -!- SUBUNIT: Heterodimerizes with protein A8 to form the virus intermediate
CC       transcription factor (VITF)-3. {ECO:0000269|PubMed:10077573}.
CC   -!- INDUCTION: Expressed in the early phase of the viral replicative cycle.
CC   -!- SIMILARITY: Belongs to the poxviruses A23 family. {ECO:0000305}.
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DR   EMBL; AY243312; AAO89422.1; -; Genomic_DNA.
DR   RefSeq; YP_233025.1; NC_006998.1.
DR   DNASU; 3707673; -.
DR   GeneID; 3707673; -.
DR   KEGG; vg:3707673; -.
DR   Proteomes; UP000000344; Genome.
DR   GO; GO:0039695; P:DNA-templated viral transcription; IDA:UniProtKB.
DR   InterPro; IPR008789; Poxvirus_intermed-TF.
DR   Pfam; PF05718; Pox_int_trans; 1.
PE   1: Evidence at protein level;
KW   Activator; Early protein; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..382
FT                   /note="Intermediate transcription factor 3 large subunit"
FT                   /id="PRO_0000099183"
SQ   SEQUENCE   382 AA;  44597 MW;  9117C4C9A702A739 CRC64;
     MDNLFTFLHE IEDRYARTIF NFHLISCDEI GDIYGLMKER ISSEDMFDNI VYNKDIHPAI
     KKLVYCDIQL TKHIINQNTY PVFNDSSQVK CCHYFDINSD NSNISSRTVE IFEREKSSLV
     SYIKTTNKKR KVNYGEIKKT VHGGTNANYF SGKKSDEYLS TTVRSNINQP WIKTISKRMR
     VDIINHSIVT RGKSSILQTI EIIFTNRTCV KIFKDSTMHI ILSKDKDEKG CIHMIDKLFY
     VYYNLFLLFE DIIQNEYFKE VANVVNHVLT ATALDEKLFL IKKMAEHDVY GVSNFKIGMF
     NLTFIKSLDH TVFPSLLDED SKIKFFKGKK LNIVALRSLE DCINYVTKSE NMIEMMKERS
     TILNSIDIET ESVDRLKELL LK