ID   VITF3_VAR67             Reviewed;         382 AA.
AC   P0DSR9; P33846; Q76PX8; Q89168;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   12-AUG-2020, entry version 5.
DE   RecName: Full=Intermediate transcription factor 3 large subunit;
DE   AltName: Full=VITF-3 45 kDa subunit;
GN   Name=VITF3L; ORFNames=A23R, A24R;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: Acts with RNA polymerase to initiate transcription from
CC       intermediate gene promoters. {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimerizes with protein A8 to form the virus intermediate
CC       transcription factor (VITF)-3. {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the early phase of the viral replicative cycle.
CC   -!- SIMILARITY: Belongs to the poxviruses A23 family. {ECO:0000305}.
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DR   EMBL; X69198; CAA49068.1; -; Genomic_DNA.
DR   PIR; F36850; F36850.
DR   RefSeq; NP_042171.1; NC_001611.1.
DR   GeneID; 1486499; -.
DR   KEGG; vg:1486499; -.
DR   Proteomes; UP000002060; Genome.
DR   InterPro; IPR008789; Poxvirus_intermed-TF.
DR   Pfam; PF05718; Pox_int_trans; 1.
PE   2: Evidence at transcript level;
KW   Activator; Early protein; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..382
FT                   /note="Intermediate transcription factor 3 large subunit"
FT                   /id="PRO_0000099184"
SQ   SEQUENCE   382 AA;  44612 MW;  641A2D7387E76770 CRC64;
     MDNLFTFLHE IEDRYTRTIF NFHLISCDEI GDIYGLMKER ISSEDMFDNI VYNKDIHPAI
     KKLVYCDIQL TKHIINQNTY PVFNDSSQVK CCHYFDINSD NSNISSRTVE IFEREKSSLV
     SYIKTTNKKR KVNYGEIKKT VHGGTNANYF SGKKSDEYLS TTVRSNINQP WIKTISKRMR
     VNIINHSIVT RGKSSILQTI EIIFTNRTCV KIFKDSTMHI ILSKDKDEKG CIHMIDKLFY
     VYYNLFLLFE DIIQNEYFKE VANVVNHVLT ATALDEKLFL IKKMAKHDVY GVSNFKIGMF
     NLTFIKSLDH TVFPSLLDED SKIKFFKGKK LNIVALRSLE DCINYVTKSE NMIEMMKERS
     TILNSIDIET ESVDRLKDLL LK