ID   VITF3_VARV              Reviewed;         382 AA.
AC   P0DSS0; P33846; Q76PX8; Q89168;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   29-SEP-2021, entry version 10.
DE   RecName: Full=Intermediate transcription factor 3 large subunit;
DE   AltName: Full=VITF-3 45 kDa subunit;
GN   Name=VITF3L; ORFNames=A23R, A24R;
OS   Variola virus.
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=10255;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bangladesh-1975;
RX   PubMed=8264798; DOI=10.1038/366748a0;
RA   Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA   Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA   Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT   "Potential virulence determinants in terminal regions of variola smallpox
RT   virus genome.";
RL   Nature 366:748-751(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Garcia-1966;
RA   Shchelkunov S.N., Totmenin A.V., Sosnovtsev S.V., Safronov P.F.,
RA   Resenchuk S.M., Blinov V.M., Sandakhchiev L.S.;
RT   "XhoI-D DNA fragment of Variola minor virus strain Garcia-1966.";
RL   Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Garcia-1966;
RX   PubMed=10639322; DOI=10.1006/viro.1999.0086;
RA   Shchelkunov S.N., Totmenin A.V., Loparev V.N., Safronov P.F., Gutorov V.V.,
RA   Chizhikov V.E., Knight J.C., Parsons J.M., Massung R.F., Esposito J.J.;
RT   "Alastrim smallpox variola minor virus genome DNA sequences.";
RL   Virology 266:361-386(2000).
CC   -!- FUNCTION: Acts with RNA polymerase to initiate transcription from
CC       intermediate gene promoters. {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimerizes with protein A8 to form the virus intermediate
CC       transcription factor (VITF)-3. {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the early phase of the viral replicative cycle.
CC   -!- SIMILARITY: Belongs to the poxviruses A23 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L22579; AAA60875.1; -; Genomic_DNA.
DR   EMBL; X76268; CAA53896.1; -; Genomic_DNA.
DR   EMBL; Y16780; CAB54727.1; -; Genomic_DNA.
DR   PIR; E72166; E72166.
DR   PIR; T28565; T28565.
DR   RefSeq; NP_042171.1; NC_001611.1.
DR   GeneID; 1486499; -.
DR   KEGG; vg:1486499; -.
DR   Proteomes; UP000111493; Genome.
DR   Proteomes; UP000119805; Genome.
DR   InterPro; IPR008789; Poxvirus_intermed-TF.
DR   Pfam; PF05718; Pox_int_trans; 1.
PE   2: Evidence at transcript level;
KW   Activator; Early protein; Transcription; Transcription regulation.
FT   CHAIN           1..382
FT                   /note="Intermediate transcription factor 3 large subunit"
FT                   /id="PRO_0000448139"
FT   VARIANT         43
FT                   /note="S -> L (in strain: Garcia-1966)"
SQ   SEQUENCE   382 AA;  44612 MW;  641A2D7387E76770 CRC64;
     MDNLFTFLHE IEDRYTRTIF NFHLISCDEI GDIYGLMKER ISSEDMFDNI VYNKDIHPAI
     KKLVYCDIQL TKHIINQNTY PVFNDSSQVK CCHYFDINSD NSNISSRTVE IFEREKSSLV
     SYIKTTNKKR KVNYGEIKKT VHGGTNANYF SGKKSDEYLS TTVRSNINQP WIKTISKRMR
     VNIINHSIVT RGKSSILQTI EIIFTNRTCV KIFKDSTMHI ILSKDKDEKG CIHMIDKLFY
     VYYNLFLLFE DIIQNEYFKE VANVVNHVLT ATALDEKLFL IKKMAKHDVY GVSNFKIGMF
     NLTFIKSLDH TVFPSLLDED SKIKFFKGKK LNIVALRSLE DCINYVTKSE NMIEMMKERS
     TILNSIDIET ESVDRLKDLL LK