VITH3_ARATH
ID VITH3_ARATH Reviewed; 200 AA.
AC Q9M2C3;
DT 27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Vacuolar iron transporter homolog 3 {ECO:0000305};
DE AltName: Full=Protein NODULIN-LIKE 3 {ECO:0000303|PubMed:21411332};
GN OrderedLocusNames=At3g43630 {ECO:0000312|Araport:AT3G43630};
GN ORFNames=F22J12.3 {ECO:0000312|EMBL:CAB83064.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=21411332; DOI=10.1016/j.plaphy.2011.02.011;
RA Gollhofer J., Schlaewicke C., Jungnick N., Schmidt W., Buckhout T.J.;
RT "Members of a small family of nodulin-like genes are regulated under iron
RT deficiency in roots of Arabidopsis thaliana.";
RL Plant Physiol. Biochem. 49:557-564(2011).
CC -!- FUNCTION: Probable vacuolar iron transporter that may be involved in
CC the regulation of iron distribution throughout the plant.
CC {ECO:0000269|PubMed:21411332}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250|UniProtKB:Q9LPU9};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- INDUCTION: Induced by iron supply. {ECO:0000269|PubMed:21411332}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC condition, but decreased accumulation of iron in the root and increased
CC accumulation in the shoot when grown under high iron concentration.
CC {ECO:0000269|PubMed:21411332}.
CC -!- SIMILARITY: Belongs to the CCC1 family. {ECO:0000305}.
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DR EMBL; AL138638; CAB83064.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77815.1; -; Genomic_DNA.
DR PIR; T47399; T47399.
DR RefSeq; NP_189949.1; NM_114231.1.
DR AlphaFoldDB; Q9M2C3; -.
DR SMR; Q9M2C3; -.
DR STRING; 3702.AT3G43630.1; -.
DR TCDB; 2.A.89.3.6; the vacuolar iron transporter (vit) family.
DR PaxDb; Q9M2C3; -.
DR PRIDE; Q9M2C3; -.
DR EnsemblPlants; AT3G43630.1; AT3G43630.1; AT3G43630.
DR GeneID; 823461; -.
DR Gramene; AT3G43630.1; AT3G43630.1; AT3G43630.
DR KEGG; ath:AT3G43630; -.
DR Araport; AT3G43630; -.
DR TAIR; locus:2080193; AT3G43630.
DR eggNOG; KOG4473; Eukaryota.
DR HOGENOM; CLU_038957_5_0_1; -.
DR InParanoid; Q9M2C3; -.
DR OMA; NGGWLRP; -.
DR OrthoDB; 1353644at2759; -.
DR PhylomeDB; Q9M2C3; -.
DR PRO; PR:Q9M2C3; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9M2C3; baseline and differential.
DR Genevisible; Q9M2C3; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005381; F:iron ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005384; F:manganese ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0030026; P:cellular manganese ion homeostasis; IBA:GO_Central.
DR GO; GO:0006880; P:intracellular sequestering of iron ion; IBA:GO_Central.
DR GO; GO:0010039; P:response to iron ion; IEP:TAIR.
DR InterPro; IPR008217; Ccc1_fam.
DR PANTHER; PTHR31851; PTHR31851; 1.
DR Pfam; PF01988; VIT1; 2.
PE 2: Evidence at transcript level;
KW Ion transport; Iron; Iron transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Vacuole.
FT CHAIN 1..200
FT /note="Vacuolar iron transporter homolog 3"
FT /id="PRO_0000411010"
FT TOPO_DOM 1..31
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..59
FT /note="Vacuolar"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..113
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..140
FT /note="Vacuolar"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..173
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 195..200
FT /note="Vacuolar"
FT /evidence="ECO:0000255"
SQ SEQUENCE 200 AA; 21192 MW; 962AFEEB5BD092CA CRC64;
MESHNTLNLD MEKDQEKAFD YSKRAQWLRA AVLGANDGLV STASLMMGVG AVKQNVKIMI
LTGFAGLVAG ACSMAIGEFV SVYSQYDIEV AQMKRETGGE IEKEKLPSPT QAAAASALAF
SLGAMVPLLA AAFVKEYKVR IGAIVAAVTL ALVMFGWLGA VLGKAPVVKS SLRVLVGGWL
AMAITYGFTK LIGSHSHMYV
