VIT_ACITR
ID VIT_ACITR Reviewed; 1677 AA.
AC Q90243;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Vitellogenin;
DE Short=VTG;
DE Contains:
DE RecName: Full=Lipovitellin I;
DE Short=LVI;
DE Contains:
DE RecName: Full=Phosvitin;
DE Short=PV;
DE Contains:
DE RecName: Full=Lipovitellin II;
DE Short=LVII;
DE Flags: Precursor; Fragment;
OS Acipenser transmontanus (White sturgeon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Chondrostei; Acipenseriformes; Acipenseridae; Acipenser.
OX NCBI_TaxID=7904;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=UC Davis Broodstock; TISSUE=Liver;
RX PubMed=7608984; DOI=10.1007/bf00174046;
RA Bidwell C.A., Carlson D.M.;
RT "Characterization of vitellogenin from white sturgeon, Acipenser
RT transmontanus.";
RL J. Mol. Evol. 41:104-112(1995).
CC -!- FUNCTION: Precursor of the major egg-yolk proteins that are sources of
CC nutrients during early development of oviparous organisms.
CC -!- TISSUE SPECIFICITY: Found in liver, testis and undifferentiated gonads
CC of estrogen-treated fish. Not detected in the brain and spleen.
CC -!- INDUCTION: By steroids (estrogen).
CC -!- PTM: Phosvitin, an egg yolk storage protein, is one of the most highly
CC phosphorylated (10%) proteins in nature. {ECO:0000250}.
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DR EMBL; U00455; AAA87392.1; -; mRNA.
DR PIR; T43021; T43021.
DR AlphaFoldDB; Q90243; -.
DR SMR; Q90243; -.
DR PRIDE; Q90243; -.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.20; -; 1.
DR Gene3D; 2.20.50.20; -; 1.
DR Gene3D; 2.20.90.10; -; 1.
DR Gene3D; 2.30.230.10; -; 1.
DR InterPro; IPR015819; Lipid_transp_b-sht_shell.
DR InterPro; IPR011030; Lipovitellin_superhlx_dom.
DR InterPro; IPR015816; Vitellinogen_b-sht_N.
DR InterPro; IPR015258; Vitellinogen_b-sht_shell.
DR InterPro; IPR037088; Vitellinogen_b-sht_shell_sf.
DR InterPro; IPR015255; Vitellinogen_open_b-sht.
DR InterPro; IPR015817; Vitellinogen_open_b-sht_sub1.
DR InterPro; IPR001747; Vitellogenin_N.
DR InterPro; IPR001846; VWF_type-D.
DR Pfam; PF09172; DUF1943; 1.
DR Pfam; PF09175; DUF1944; 1.
DR Pfam; PF01347; Vitellogenin_N; 1.
DR Pfam; PF00094; VWD; 1.
DR SMART; SM01169; DUF1943; 1.
DR SMART; SM01170; DUF1944; 1.
DR SMART; SM00638; LPD_N; 1.
DR SMART; SM00216; VWD; 1.
DR SUPFAM; SSF48431; SSF48431; 1.
DR SUPFAM; SSF56968; SSF56968; 3.
DR PROSITE; PS51211; VITELLOGENIN; 1.
DR PROSITE; PS51233; VWFD; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Phosphoprotein; Signal; Storage protein.
FT SIGNAL <1..8
FT /evidence="ECO:0000255"
FT CHAIN 9..1677
FT /note="Vitellogenin"
FT /id="PRO_0000041576"
FT CHAIN 9..?1091
FT /note="Lipovitellin I"
FT /id="PRO_0000041577"
FT CHAIN ?1092..?1300
FT /note="Phosvitin"
FT /id="PRO_0000041578"
FT CHAIN ?1301..1677
FT /note="Lipovitellin II"
FT /id="PRO_0000041579"
FT DOMAIN 17..655
FT /note="Vitellogenin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00557"
FT DOMAIN 1490..1675
FT /note="VWFD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT REGION 1089..1232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1252..1280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1636..1659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1089..1123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1124..1153
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1167..1201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1208..1232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1255..1280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 1182
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1202
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1217
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1218
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 1492..1631
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 1515..1674
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT NON_TER 1
SQ SEQUENCE 1677 AA; 186022 MW; 5F49DA86E434DC35 CRC64;
LTIALVGSQQ TKYEPSFSGS KTYQYKYEGV ILTGLPEKGL ARAGLKVHCK VEISEVAQKT
YLLKILNPEI QEYNGIWPKA PFYPASKLTQ ALASQLTQPI KFQYRNGQVG DIFASEDVSD
TVLNIQRGIL NMLQLTIKTT QNVYGLQENG IAGICEASYV IQEDRKANKI IVTKSKDLNN
CNEKIKMDIG MAYSHTCSNC RKIRKNTRGT AAYTYILKPT DTGTLITQAT SQEVHQLTPF
NEMTGAAITE ARQKLVLEDA KVIHVTVPEQ ELKNRGSIQY QFASEILQTP IQLFKTRSPE
TKIKEVLQHL VQNNQQQVQS DAPSKFLQLT QLLRACTHEN IEGIWRQYEK TQLYRRWILD
ALPAAATPTA FRFITQRIMK RDLTDAEAIQ TLVTAMHLVQ TNHQIVQMAA ELVFDRANLK
CPVLRKHAVL AYGSMVNRYC AETLNCREEA LKPLHDFAND AISRAHEEET VLALKALGNA
GQPSSIKRIQ KCLPGFSSGA SQLPVKIQVD AVMALRNIAK KEPGKVQELT MQLFMDHQLH
SEVRMVASMV LLETRPSMAL VATLAEALLK ETSLQVASFT YSHMKAITRS TAPENHALSS
ACNVAVKLLS RKLDRLSYRY SKAMHMDTFK YPLMAGAAAN IHIINNAASI LPSAVVMKFQ
AYILSATADP LEIGLHTEGL QEVLMQNHEH IDQMPSAGKI QQIMKMLSGW KSVPSEKTLA
SAYIKLFGQE ISFSRLDKKT IQEALQAVRE PVERQTVIKR VVNQLERGAA AQLSKPLLVA
EVRRILPTCI GLPMEMSLYV SAVTTADINV QAHITPSPTN DFNVAQLLNS NIVLHTDVTP
SIAMHTIAVM GINTHVIQTG VELHVKARTT VPMKFTAKID LKEKNFKIES EPCQQETEVL
SLSAQAFAIS RNVEDLDAAK KNPLLPEEAV RNILNEQFNS GTEDSNERER AGKFARPSAE
MMSQELMNSG EHQNRKGAHA TRSACAKAKN FGFEVCFEGK SENVAFLRDS PLYKIIGQHH
CKIALKPSHS SEATIEKIQL ELQTGNKAAS KIIRVVAMQS LAEADEMKGN ILKKLNKLLT
VDGETQDSTL RGFKRRSSSS SSSSSSSSSS SSSSSSSSSQ QSRMEKRMEQ DKLTENLERD
RDHMRGKQSK NKKQEWKNKQ KKHHKQLPSS SSSSSSSSSG SNSSSSSSSS SSSSSRSHNH
RNNTRTLSKS KRYQNNNNSS SSSGSSSSSE EIQKNPEIFA YRFRSHRDKL GFQNKRGRMS
SSSSSSSSSS SQSTLNSKQD AKFLGDSSPP IFAFVARAVR SDGLQQGYQV AAYTDNRVSR
PRVQLLATEI IEKSRWQICA DAILASNYKA MALMRWGEEC QDYKVAVSAV TGRLASHPSL
QIKAKWSRIP RAAKQTQNIL AEYVPGAAFM LGFSQKEQRN PSKQFKIILA VTSPNTIDTL
IKAPKITLFK QAVQIPVQIP MEPSDAERRS PGLASIMNEI PFLIEEATKS KCVAQENKFI
TFDGVKFSYQ MPGGCYHILA QDCRSKVRFM VMLKQASMSK NLRAVNAKIY NKDIDILPTT
KGSVRLLINN NEIPLSQLPF TDSSGNIHIK RADEGVSVSA QQYGLESLYF DGKTVQVKVT
SEMRGKTCGL CGHNDGERRK EFRMPDGRQA RGPSVSPTPG LCLEKTATEA ASFCVIM
