VIT_PENME
ID VIT_PENME Reviewed; 2586 AA.
AC Q6RG02;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 2.
DT 25-MAY-2022, entry version 54.
DE RecName: Full=Vitellogenin;
DE Contains:
DE RecName: Full=Vitellin;
DE Flags: Precursor;
OS Penaeus merguiensis (Banana prawn) (Fenneropenaeus merguiensis).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC Penaeoidea; Penaeidae; Penaeus.
OX NCBI_TaxID=71412;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAR88442.2}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Ovary {ECO:0000312|EMBL:AAR88442.2};
RX PubMed=16432892; DOI=10.1002/mrd.20424;
RA Phiriyangkul P., Utarabhand P.;
RT "Molecular characterization of a cDNA encoding vitellogenin in the banana
RT shrimp, Penaeus (Litopenaeus) merguiensis and sites of vitellogenin mRNA
RT expression.";
RL Mol. Reprod. Dev. 73:410-423(2006).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAR88442.2}
RP PROTEIN SEQUENCE OF 19-28, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP GLYCOSYLATION.
RC TISSUE=Ovary {ECO:0000312|EMBL:AAR88442.2};
RX PubMed=16289995; DOI=10.1016/j.cbpb.2005.09.009;
RA Auttarat J., Phiriyangkul P., Utarabhand P.;
RT "Characterization of vitellin from the ovaries of the banana shrimp
RT Litopenaeus merguiensis.";
RL Comp. Biochem. Physiol. 143B:27-36(2006).
CC -!- FUNCTION: Precursor of the egg-yolk proteins that are sources of
CC nutrients during embryonic development. {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in the ovary and hepatopancrease of
CC vitellogenic females. Not expressed in the muscle, heart and intestine
CC of female or in the hepatopancrease of the male. Detected in the ovary
CC and hemolymph of female (at protein level). Not detected in the female
CC hepatopancreas or in the male hemolymph and testis (at protein level).
CC {ECO:0000269|PubMed:16289995, ECO:0000269|PubMed:16432892}.
CC -!- DEVELOPMENTAL STAGE: Vitellogenin is detected in stage 1 of the ovarian
CC cycle and protein levels increase to reach a maximum in stage 3.
CC Thereafter vitellogen levels in the ovary decrease gradually. Vitellin
CC is detected at low levels in stage 1 of the ovarian cycle and protein
CC levels increase steadily in stages 2 through to 4.
CC {ECO:0000269|PubMed:16289995}.
CC -!- PTM: Glycosylated. {ECO:0000269|PubMed:16289995}.
CC -!- PTM: May be modified covalently by lipidation.
CC {ECO:0000269|PubMed:16289995}.
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DR EMBL; AY499620; AAR88442.2; -; mRNA.
DR AlphaFoldDB; Q6RG02; -.
DR SMR; Q6RG02; -.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0005319; F:lipid transporter activity; IDA:UniProtKB.
DR GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR GO; GO:0048477; P:oogenesis; IEP:UniProtKB.
DR Gene3D; 1.25.10.20; -; 1.
DR Gene3D; 2.20.50.20; -; 1.
DR Gene3D; 2.30.230.10; -; 1.
DR InterPro; IPR015819; Lipid_transp_b-sht_shell.
DR InterPro; IPR009454; Lipid_transpt_open_b-sht.
DR InterPro; IPR011030; Lipovitellin_superhlx_dom.
DR InterPro; IPR015816; Vitellinogen_b-sht_N.
DR InterPro; IPR015255; Vitellinogen_open_b-sht.
DR InterPro; IPR015817; Vitellinogen_open_b-sht_sub1.
DR InterPro; IPR001747; Vitellogenin_N.
DR InterPro; IPR001846; VWF_type-D.
DR Pfam; PF06448; DUF1081; 1.
DR Pfam; PF09172; DUF1943; 1.
DR Pfam; PF01347; Vitellogenin_N; 1.
DR SMART; SM01169; DUF1943; 1.
DR SMART; SM00638; LPD_N; 1.
DR SUPFAM; SSF48431; SSF48431; 1.
DR SUPFAM; SSF56968; SSF56968; 2.
DR PROSITE; PS51211; VITELLOGENIN; 1.
DR PROSITE; PS51233; VWFD; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Glycoprotein; Lipid transport;
KW Lipid-binding; Lipoprotein; Signal; Storage protein; Transport.
FT SIGNAL 1..18
FT /evidence="ECO:0000269|PubMed:16289995"
FT CHAIN 19..2586
FT /note="Vitellogenin"
FT /evidence="ECO:0000269|PubMed:16289995"
FT /id="PRO_0000259413"
FT CHAIN 19..?
FT /note="Vitellin"
FT /evidence="ECO:0000269|PubMed:16289995"
FT /id="PRO_0000259414"
FT DOMAIN 42..653
FT /note="Vitellogenin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00557"
FT DOMAIN 2353..2516
FT /note="VWFD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 170..194
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00557,
FT ECO:0000255|PROSITE-ProRule:PRU00580"
FT DISULFID 2378..2515
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
SQ SEQUENCE 2586 AA; 283029 MW; E68C3991C9783F06 CRC64;
MTTSTLLFVL AFVAGGLAAP WGADVPRCST ECPVTGSPKL AYQPDKTYAY AYSGKSTVQL
KGVDNGDTET EWTAGVDLTW ISPCDMAISF RNTKMDGARG PTAARTLERY PLVVAVVDGR
VQHVCAHPED EAWAINLKKG VASAFQNSIP SLSAVSSGIT VTETDVVGKC PTKYEIETEG
EKVIVVKEKN HRHCQERYPT PAALPAPWLK APLPIEESKS QCRQEIANGI YTAITCQDKN
IVRPAIGIYK YVEASQYSTL RFISESSDTS AISGIPSGEL NIESLLYNHE TMKDPQLAPE
LDELMKEICD KTKDTVEAEA GALVAKALHV LRRIPDTVVV ETAQKVRQGH YCSDSARLES
IFLDAVAFIH ESGAVKVMVN EIENGRATGG RLALYTAALY LIPRPNIEAV KALTPLFESP
RPMPSLLLAA ATMVNHYCRH TPACYEKAPV ARIAEILANR VQTHCSPSAG VEDNEVALAI
FKTIGNMGVA TPAVTRAAVH CIEVEGLETS VRVAAAEAFR QANCFRPAVE KLVDIAVRPA
FETEVRIASY LAAVRCAEQE HLETIIEKIS KEENTQVRGF VLGHLINIQE STCPAKENLR
YLLANVIPTD FERDFRKFSR NIDVAYHAPA FGMGAGLESN IIYAPGSFVP RAVNLKMKAD
VDETHMDIAE IGARFVGIES IIEEPLGPQG YLRTATFGKI MEDITGFAGE KGYKVMEQLK
HTLRTRRSID SSVIADFFGK LYGKSRSHTH AELFARFMGH EITYADVAGS LKGVTADTLI
ETFFSFFENS LEHMKDLNLN TARTAQLSMD YSLPTIQGTP LRLRLAGTAV AGLKMEGNVN
IAQILSDLGN SQTGVKFFPG LSVHATGFVG FDWLLARVGI EMQNTISSAT GAAIKIRTTE
NKKIEMELEV PEKMELLNIK AETYLVKAVG KKMTEISPSS MRDVRIQRNS CIGALEPVFG
LKVCYDMNIP DVFRANALPL GEPAIAKLYV EKADPSMRGY LVTAAIKNKR GNKVIKMNVE
AAGASTPRRA EMTLSYTKEE GSHIVSAKLD SSSIAAGVWT TLTNEQGHKA METYVNFNYG
QIAISRGIKL EAIAREASVG EEFQVNVFSS GTRSFPSESH IVEARFIKKT SGPEFNVDVI
CRTKNALAEL FDLNIEVGAD FMKFSPKNLY PARYIPKTRI VLPVNLRKME INAATAAWKL
ISYIRAGSQS GGSREFISAL KLAKGRKDFI SVQATHTIEG TFPQNIIIKN VATAEVGRSS
YKAMYDLFYH SEKMGASLEV LQAAGNEKVA HLEAIYELSG SKYCTKFLAE IPGYIQPVKV
EAGIEQGAEG RYTLESAITY GQRTVLEASG PIMARFSSKI AKLQANIKVR AMASEPYIIG
ANVAFGSKKQ MIAMEIKGRS EAVIGLEWKM VRESSEKTTV GIVFVLPALI ENKIDAEITD
GLIHVSFNNL VLPKTSSRRR VKGFADVHIA EKKANVEFSW DADNAPEKKL VLDASLISSS
ANPGHAEIHG NIVIAGEPFH AKLVLTAANL VEHMEGENGF KLILTTPSQK TIVLGASCDV
QVAGATTKVI STVEYKNMKD RKYKYASVIA YEKLGGPFDY AVEAKVTYKQ PGTAEIKLGT
AVKHHWTPEE HVVAVRVEAD APILKTPATI EFSIHNAPNA FVGFCKIERN APATVFEWNV
QITPEGGIEA VEAGVDMKAI IEVLKIVHAA ATLQEESYET YGPHTSQYQY RFTRPSPTSY
TMQMRTPTRT MEGRAKLSPR ESGIKFYPNK GKTESKYEIG YKANHEGRWG GHASKLEVRM
NHPVLPKPIM AAVQYTVAEE TTKGTIELDI FPEEANKITG SLETQRISEN AIRAEAFLTS
RMLKVNPKAI ITAAYAPETV AFDVVFHKTP SAAPIFAIAA KYDKTAAHNA AATFTVKMEE
RPVFEITAVT EPEEAATCNG IRMRAVAYAA TFGKYNVISK MCRPAFIEVT AMRPGGAKEY
IAKLGLRYPD AAEAGVYVAS GRAGETHGVA VAAVKLASPT MLKVEMAYEP QEAEAIINEM
TEEFEKIAAS FTSVEMEVVE FLKQEAAAKG IQFPSSQLVN LLGVAKEEIA EIYRDIVSEA
IIFDTEILGD ILGSPVVSFI SRVYFGVWSE IIHLQHHLSV SLIQTIERFQ QELGSISEIL
MEVVMTAARM AETGEVPGVV FDALEEIKAT KVFRIVRREV DAILEEYPEE YEAVKHIVHN
VVAILKRDVG IVRERLMEIP AVLKIIDYTM YHFHSERAFA AEAEKLVSLM LNELLFVSME
REGNGVAVRI PLHRPLYSLT QVAQEAVPNP VTMLENLIFA YVDYIPIPVS DAIWAFYNLV
PRYITDVLPP YPRTATVVGG SEILTFSGLV VRAPRSPCKV VLAAHGSHRL MMSHPQASAP
AQFELKTPAA TVMIKPDFEV VVNGQPLAGS QQTIGNVRIV NTAEHIEVGC PLMKVVVAKA
GEAVAVEASG WVFGRVAGLL GPNNGEIAHD RLMPSGAAAS NPRDLVAAWQ EDRQCSTPEV
PRAETTVARL IQCEALLGIR SRCNPVVHPQ PFIKMCHAAH KACDAAQAYR TVCSLRGVGE
VFPLGC
