ID   VIT_TAKPA               Reviewed;         229 AA.
AC   A0A292G9J6; C0HK78; C0HK97;
DT   25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT   25-APR-2018, sequence version 2.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Vitellogenin {ECO:0000305};
DE   Contains:
DE     RecName: Full=Toxin-binding protein TPOBP-10 {ECO:0000303|PubMed:28651990};
DE     AltName: Full=Ovary toxin-binding protein 10 kDa {ECO:0000303|PubMed:28651990};
DE              Short=TPOBP-10 {ECO:0000303|PubMed:28651990};
DE   Flags: Fragment;
OS   Takifugu pardalis (Panther puffer) (Tetraodon pardalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=98921 {ECO:0000312|EMBL:BBA57169.1};
RN   [1] {ECO:0000312|EMBL:BBA57169.1}
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 18-229, PROTEIN SEQUENCE OF 1-29, PROBABLE
RP   FUNCTION OF TOXIN-BINDING PROTEIN TPOBP-10, TISSUE SPECIFICITY, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Liver {ECO:0000312|EMBL:BBA57169.1}, and
RC   Ovary {ECO:0000303|PubMed:28651990};
RX   PubMed=28651990; DOI=10.1016/j.toxicon.2017.06.006;
RA   Yin X., Kiriake A., Ohta A., Kitani Y., Ishizaki S., Nagashima Y.;
RT   "A novel function of vitellogenin subdomain, vWF type D, as a toxin-binding
RT   protein in the pufferfish Takifugu pardalis ovary.";
RL   Toxicon 136:56-66(2017).
CC   -!- FUNCTION: Precursor of the egg-yolk proteins that are sources of
CC       nutrients during early development of oviparous organisms.
CC       {ECO:0000305}.
CC   -!- FUNCTION: [Toxin-binding protein TPOBP-10]: Probably binds tetrodotoxin
CC       in the ovary. {ECO:0000269|PubMed:28651990}.
CC   -!- TISSUE SPECIFICITY: Expressed in liver, ovary and, to a lesser extent,
CC       in muscle, intestine, skin, kidney and heart.
CC       {ECO:0000269|PubMed:28651990}.
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DR   EMBL; LC190510; BBA57169.1; -; mRNA.
DR   AlphaFoldDB; A0A292G9J6; -.
DR   GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR   InterPro; IPR001846; VWF_type-D.
DR   Pfam; PF00094; VWD; 1.
DR   PROSITE; PS51233; VWFD; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Storage protein.
FT   CHAIN           <1..>229
FT                   /note="Vitellogenin"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000443996"
FT   CHAIN           1..?
FT                   /note="Toxin-binding protein TPOBP-10"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000443997"
FT   DOMAIN          <1..136
FT                   /note="VWFD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00580"
FT   CARBOHYD        198
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT                   /evidence="ECO:0000312|EMBL:BBA57169.1"
FT   NON_TER         229
FT                   /evidence="ECO:0000312|EMBL:BBA57169.1"
SQ   SEQUENCE   229 AA;  25337 MW;  18731874DCC79881 CRC64;
     IVMLKNDNVE QKHINIKIAD IDIDLFPKSG NIGVKVNGVE IPMENLPYYH PTVKIQIRQK
     GEGISVVAPS LGLSEVYMDS KSWKVEVVDW MKGQTCGLCG KADGEIKQEF RMPNGHLTKN
     AVTYAHSWIL AAESCRDNSE CRIKLDSVEL EKRAVIYGQE SRCFSVEPVL RCLPGCFPVK
     TTSVTVGFHC VAADSNVNKS EVLRGIQGKR VDLREKADAH LACSCTAQC