ID   VIUB_VIBC3              Reviewed;         271 AA.
AC   A5F660; C3M3G7; Q56646; Q9JQ01;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Vibriobactin utilization protein ViuB;
GN   Name=viuB; OrderedLocusNames=VC0395_A1802, VC395_2326;
OS   Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 /
OS   O395).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=345073;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN THE INTRACELLULAR
RP   UTILIZATION OF FERRIC VIBRIOBACTIN, INDUCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=8083157; DOI=10.1128/jb.176.18.5631-5638.1994;
RA   Butterton J.R., Calderwood S.B.;
RT   "Identification, cloning, and sequencing of a gene required for ferric
RT   vibriobactin utilization by Vibrio cholerae.";
RL   J. Bacteriol. 176:5631-5638(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Liao W.J., Choi M.H., Butterton J.R.;
RL   Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RA   Heidelberg J.;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RX   PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA   Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA   Wang W., Wang J., Qian W., Li D., Wang L.;
RT   "A recalibrated molecular clock and independent origins for the cholera
RT   pandemic clones.";
RL   PLoS ONE 3:E4053-E4053(2008).
CC   -!- FUNCTION: Involved in intracellular removal of iron from iron-
CC       vibriobactin complex. Vibriobactin is an iron-chelating compound
CC       involved in the transport of iron from the bacterial environment into
CC       the cell cytoplasm. {ECO:0000269|PubMed:8083157}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: By iron starvation and Fur. {ECO:0000269|PubMed:8083157}.
CC   -!- DISRUPTION PHENOTYPE: Cells lacking this gene are unable to utilize
CC       exogenous ferric vibriobactin but synthesize the siderophore normally.
CC       {ECO:0000269|PubMed:8083157}.
CC   -!- SIMILARITY: Belongs to the SIP oxidoreductase family. {ECO:0000305}.
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DR   EMBL; AF030977; AAB86829.1; -; Genomic_DNA.
DR   EMBL; CP000627; ABQ22022.1; -; Genomic_DNA.
DR   EMBL; CP001235; ACP10316.1; -; Genomic_DNA.
DR   RefSeq; WP_000064348.1; NZ_JAACZH010000022.1.
DR   AlphaFoldDB; A5F660; -.
DR   SMR; A5F660; -.
DR   STRING; 345073.VC395_2326; -.
DR   EnsemblBacteria; ABQ22022; ABQ22022; VC0395_A1802.
DR   GeneID; 57740836; -.
DR   KEGG; vco:VC0395_A1802; -.
DR   KEGG; vcr:VC395_2326; -.
DR   PATRIC; fig|345073.21.peg.2242; -.
DR   eggNOG; COG2375; Bacteria.
DR   HOGENOM; CLU_040923_3_1_6; -.
DR   OMA; PYAWIAG; -.
DR   Proteomes; UP000000249; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   GO; GO:0019536; P:vibriobactin metabolic process; IMP:UniProtKB.
DR   Gene3D; 3.40.50.80; -; 1.
DR   InterPro; IPR013113; FAD-bd_9_SIP.
DR   InterPro; IPR017927; FAD-bd_FR_type.
DR   InterPro; IPR039261; FNR_nucleotide-bd.
DR   InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR   InterPro; IPR007037; SIP_C.
DR   InterPro; IPR039374; SIP_fam.
DR   PANTHER; PTHR30157; PTHR30157; 1.
DR   Pfam; PF08021; FAD_binding_9; 1.
DR   Pfam; PF04954; SIP; 1.
DR   SUPFAM; SSF63380; SSF63380; 1.
DR   PROSITE; PS51384; FAD_FR; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Ion transport; Iron; Iron transport; Transport.
FT   CHAIN           1..271
FT                   /note="Vibriobactin utilization protein ViuB"
FT                   /id="PRO_0000324782"
FT   DOMAIN          8..131
FT                   /note="FAD-binding FR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00716"
SQ   SEQUENCE   271 AA;  30515 MW;  B6B6AE40ACE6A8EC CRC64;
     MSNEVERVYP RLLDFVRKKY VSKNLLRVTL TGEDLIGFPE DQNGSHIKVF FPNQASGILQ
     LPIREGDKVI WPEHKPVPRA YTVRQYRAQS NELDIDFVVH GEGTPGGGWA LKAQTGSQLG
     LIGPGGPDPL IEPADWHIMA GDLSAVPAIS AILEKMPSQA KGYVFLEVDD IEDKHDISHP
     EQMVIKWLVR DPNQAQPVLA MAIEQLPVPQ GAESLSAFVA GENESVIACR KILRNEYRIA
     RDKIYAIPYW KRGKNEEAYH EERHVVMDEE F