ID   VJBR_BRUO2              Reviewed;         259 AA.
AC   A5VTN1;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=HTH-type quorum sensing-dependent transcriptional regulator VjbR;
GN   Name=vjbR; OrderedLocusNames=BOV_A0110;
OS   Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=444178;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25840 / 63/290 / NCTC 10512;
RX   PubMed=19436743; DOI=10.1371/journal.pone.0005519;
RA   Tsolis R.M., Seshadri R., Santos R.L., Sangari F.J., Lobo J.M.,
RA   de Jong M.F., Ren Q., Myers G., Brinkac L.M., Nelson W.C., Deboy R.T.,
RA   Angiuoli S., Khouri H., Dimitrov G., Robinson J.R., Mulligan S.,
RA   Walker R.L., Elzer P.E., Hassan K.A., Paulsen I.T.;
RT   "Genome degradation in Brucella ovis corresponds with narrowing of its host
RT   range and tissue tropism.";
RL   PLoS ONE 4:E5519-E5519(2009).
CC   -!- FUNCTION: Transcriptional regulator involved in the global control of
CC       Brucella gene expression. Mediates the effects of the quorum sensing
CC       autoinducer C12-HSL (N-dodecanoyl-homoserine lactone) on a large and
CC       diverse number of genes. {ECO:0000250|UniProtKB:Q8YAY5}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABQ62475.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000709; ABQ62475.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_006015076.1; NC_009504.1.
DR   AlphaFoldDB; A5VTN1; -.
DR   SMR; A5VTN1; -.
DR   EnsemblBacteria; ABQ62475; ABQ62475; BOV_A0110.
DR   GeneID; 45125534; -.
DR   KEGG; bov:BOV_A0110; -.
DR   HOGENOM; CLU_072786_7_0_5; -.
DR   PhylomeDB; A5VTN1; -.
DR   Proteomes; UP000006383; Chromosome II.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.80; -; 1.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR005143; TF_LuxR_autoind-bd_dom.
DR   InterPro; IPR036693; TF_LuxR_autoind-bd_dom_sf.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF03472; Autoind_bind; 1.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF75516; SSF75516; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Quorum sensing; Transcription; Transcription regulation.
FT   CHAIN           1..259
FT                   /note="HTH-type quorum sensing-dependent transcriptional
FT                   regulator VjbR"
FT                   /id="PRO_0000319928"
FT   DOMAIN          183..248
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        207..226
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   REGION          76..179
FT                   /note="C12-HSL binding"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   259 AA;  28607 MW;  32388FA564A2571D CRC64;
     MSLDLVHFPN YKKTFFGSSF QSDTLALLTR IRDEIGCRYV THTYRGRVGD CTKVNSADLT
     VLITLPATWV ARYSSKNYFA IDPVFQEDAP YYRNDTSAIA RDLKEDADIC PAVAELLHDA
     EKHGLGNLFI AVSARNPKGV AGCTVFTFEV EDEDRTQFLA RMRPRLLSLA GIIHGTVCGC
     KDANSVASLL TPREVDCLRW AANGKTDGEI AEILSIARWT VVTYLQNAKI KLNCSNRTSA
     VATALSLGII DMPEVQHLV