ID   VJBR_BRUSU              Reviewed;         259 AA.
AC   Q8FXF9; G0KEW3;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=HTH-type quorum sensing-dependent transcriptional regulator VjbR;
GN   Name=vjbR; OrderedLocusNames=BRA0119, BS1330_II0118;
OS   Brucella suis biovar 1 (strain 1330).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=204722;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=12271122; DOI=10.1073/pnas.192319099;
RA   Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA   Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA   Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA   Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E.,
RA   Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L.,
RA   Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
RT   "The Brucella suis genome reveals fundamental similarities between animal
RT   and plant pathogens and symbionts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=22038969; DOI=10.1128/jb.06181-11;
RA   Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.;
RT   "Revised genome sequence of Brucella suis 1330.";
RL   J. Bacteriol. 193:6410-6410(2011).
CC   -!- FUNCTION: Transcriptional regulator involved in the global control of
CC       Brucella gene expression. Mediates the effects of the quorum sensing
CC       autoinducer C12-HSL (N-dodecanoyl-homoserine lactone) on a large and
CC       diverse number of genes. {ECO:0000250|UniProtKB:Q8YAY5}.
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DR   EMBL; AE014292; AAN33328.1; -; Genomic_DNA.
DR   EMBL; CP002998; AEM19607.1; -; Genomic_DNA.
DR   RefSeq; WP_002966460.1; NZ_KN046805.1.
DR   AlphaFoldDB; Q8FXF9; -.
DR   SMR; Q8FXF9; -.
DR   EnsemblBacteria; AEM19607; AEM19607; BS1330_II0118.
DR   GeneID; 45053211; -.
DR   GeneID; 55591850; -.
DR   KEGG; bms:BRA0119; -.
DR   KEGG; bsi:BS1330_II0118; -.
DR   PATRIC; fig|204722.22.peg.2909; -.
DR   HOGENOM; CLU_072786_7_0_5; -.
DR   OMA; RESLQWV; -.
DR   PhylomeDB; Q8FXF9; -.
DR   PRO; PR:Q8FXF9; -.
DR   Proteomes; UP000007104; Chromosome II.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.80; -; 1.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR005143; TF_LuxR_autoind-bd_dom.
DR   InterPro; IPR036693; TF_LuxR_autoind-bd_dom_sf.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF03472; Autoind_bind; 1.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF75516; SSF75516; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Quorum sensing; Transcription; Transcription regulation.
FT   CHAIN           1..259
FT                   /note="HTH-type quorum sensing-dependent transcriptional
FT                   regulator VjbR"
FT                   /id="PRO_0000319929"
FT   DOMAIN          183..248
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        207..226
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   REGION          76..179
FT                   /note="C12-HSL binding"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   259 AA;  28625 MW;  2D845BA0737094CC CRC64;
     MSLDLVHFPN YKKTFFGSSF QSDTLALLTR IRDEIGCRYV THTYRGRVGD CTKVNSADLT
     VLMTLPATWV ARYSSKNYFA IDPVFQEDAP YYRNDTSAIA RDLKEDADIC PAVAELLHDA
     EKHGLGNLFI AVSARNPKGV AGCTVFTFEV EDEDRTQFLA RMRPRLLSLA GIIHGTVCGC
     KDANSVASLL TPREVDCLRW AANGKTDGEI AEILSIARWT VVTYLQNAKI KLNCSNRTSA
     VATALSLGII DMPEVQHLV