ID   VKT1L_BUNMU             Reviewed;          82 AA.
AC   B4ESA2;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Kunitz-type serine protease inhibitor PILP-1;
DE   AltName: Full=Protease inhibitor-like protein 1;
DE   Flags: Precursor;
OS   Bungarus multicinctus (Many-banded krait).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Bungarinae; Bungarus.
OX   NCBI_TaxID=8616;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   TISSUE=Liver;
RX   PubMed=18471842; DOI=10.1016/j.toxicon.2008.03.025;
RA   Chang L.-S., Wang J.-J., Cheng Y.-C., Chou W.-M.;
RT   "Genomic DNAs encoding Bungarus multicinctis protease inhibitor-like
RT   proteins.";
RL   Toxicon 51:1490-1495(2008).
CC   -!- FUNCTION: Serine protease inhibitor that inhibits trypsin (Ki=55.62
CC       nM). {ECO:0000269|PubMed:18471842}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the venom Kunitz-type family. {ECO:0000305}.
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DR   EMBL; AM939781; CAP74381.1; -; Genomic_DNA.
DR   AlphaFoldDB; B4ESA2; -.
DR   SMR; B4ESA2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd00109; KU; 1.
DR   Gene3D; 4.10.410.10; -; 1.
DR   InterPro; IPR002223; Kunitz_BPTI.
DR   InterPro; IPR036880; Kunitz_BPTI_sf.
DR   InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR   Pfam; PF00014; Kunitz_BPTI; 1.
DR   PRINTS; PR00759; BASICPTASE.
DR   SMART; SM00131; KU; 1.
DR   SUPFAM; SSF57362; SSF57362; 1.
DR   PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR   PROSITE; PS50279; BPTI_KUNITZ_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Protease inhibitor; Secreted; Serine protease inhibitor;
KW   Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000250"
FT   CHAIN           25..82
FT                   /note="Kunitz-type serine protease inhibitor PILP-1"
FT                   /id="PRO_5000388067"
FT   DOMAIN          30..80
FT                   /note="BPTI/Kunitz inhibitor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   SITE            40..41
FT                   /note="Reactive bond for trypsin"
FT                   /evidence="ECO:0000250"
FT   DISULFID        30..80
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        39..63
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        55..76
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
SQ   SEQUENCE   82 AA;  9259 MW;  658559BD0358C248 CRC64;
     MSSGSLLLLL GLLTLWAELT PISTKDRPSC DKAPDTERCK RNVYAFYYNP SARDCLQFVY
     GGCDGNGKHF RSKALCLFHC HR