ID   CALB_CAUVC              Reviewed;         485 AA.
AC   Q9A777;
DT   11-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Probable coniferyl aldehyde dehydrogenase;
DE            Short=CALDH;
DE            EC=1.2.1.68;
GN   Name=calB; OrderedLocusNames=CC_1849;
OS   Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=190650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA   Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA   Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA   Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(E)-coniferaldehyde + H2O + NADP(+) = (E)-ferulate + 2 H(+) +
CC         NADPH; Xref=Rhea:RHEA:23964, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16547, ChEBI:CHEBI:29749, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58349; EC=1.2.1.68;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(E)-coniferaldehyde + H2O + NAD(+) = (E)-ferulate + 2 H(+) +
CC         NADH; Xref=Rhea:RHEA:23968, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16547, ChEBI:CHEBI:29749, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945; EC=1.2.1.68;
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; AE005673; AAK23824.1; -; Genomic_DNA.
DR   PIR; D87478; D87478.
DR   RefSeq; NP_420656.1; NC_002696.2.
DR   RefSeq; WP_010919715.1; NC_002696.2.
DR   AlphaFoldDB; Q9A777; -.
DR   SMR; Q9A777; -.
DR   STRING; 190650.CC_1849; -.
DR   EnsemblBacteria; AAK23824; AAK23824; CC_1849.
DR   KEGG; ccr:CC_1849; -.
DR   PATRIC; fig|190650.5.peg.1867; -.
DR   eggNOG; COG1012; Bacteria.
DR   HOGENOM; CLU_005391_3_6_5; -.
DR   OMA; RRITWAA; -.
DR   BioCyc; CAULO:CC1849-MON; -.
DR   Proteomes; UP000001816; Chromosome.
DR   GO; GO:0050269; F:coniferyl-aldehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006081; P:cellular aldehyde metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR029510; Ald_DH_CS_GLU.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR012394; Aldehyde_DH_NAD(P).
DR   PANTHER; PTHR43570; PTHR43570; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PIRSF; PIRSF036492; ALDH; 1.
DR   SUPFAM; SSF53720; SSF53720; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..485
FT                   /note="Probable coniferyl aldehyde dehydrogenase"
FT                   /id="PRO_0000056586"
FT   ACT_SITE        226
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
FT   ACT_SITE        260
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10007"
SQ   SEQUENCE   485 AA;  52721 MW;  8222ABB2DC5E78C1 CRC64;
     MNAPVNLSSD AHKAVMNDVL QRQKAAHLRD GPPSAEKRIQ WLNRCIDLLV GHQAEIAKAV
     NQDFGSRSPE ATSLTDVAGS IGPLKHAREH LTKWMKPEKH KTTPAILGLF GAKATVQWQP
     KGVVGVISPW NFPVNLTFAP LAGVFAAGNR AMIKPSEFTP ATSDLLKAMF AKAFNEEEVA
     VFVGGPEVGQ AFSGLAFDHL VFTGATSVAK HVMRAAAENL VPVTLELGGK SPVILSRGAD
     MATAAARVMN GKTLNAGQIC LAPDYVLAPQ EDVEAFVKEA QAAVSRYFPT IKDNPDYTAV
     VAQRHYDRVK GYVDDARAKG ARVIEINPAG EDLSQQEHRK IPPTLILDPT DDMKVMQEEI
     FGPVLPVKGY KTVDEAVDYV NAHDRPLALY WFGTDEAEKD RVLERTTSGG VTVNDVIFHV
     AQENLPFGGI GPAGMGAYHG YDGFREFSHR KAVFQQLKKD IAPMLGLRPP YGEGIRKYLA
     GQIKK