ID   VKT25_CYRHA             Reviewed;          33 AA.
AC   P0CH75;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 1.
DT   03-AUG-2022, entry version 29.
DE   RecName: Full=Kunitz-type serine protease inhibitor hainantoxin F7-25.66;
DE   AltName: Full=Peptide F7-25.66;
DE   Flags: Fragment;
OS   Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Theraphosidae; Haplopelma.
OX   NCBI_TaxID=209901;
RN   [1]
RP   PROTEIN SEQUENCE, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=20192277; DOI=10.1021/pr1000016;
RA   Tang X., Zhang Y., Hu W., Xu D., Tao H., Yang X., Li Y., Jiang L.,
RA   Liang S.;
RT   "Molecular diversification of peptide toxins from the tarantula Haplopelma
RT   hainanum (Ornithoctonus hainana) venom based on transcriptomic, peptidomic,
RT   and genomic analyses.";
RL   J. Proteome Res. 9:2550-2564(2010).
CC   -!- FUNCTION: Serine protease inhibitor that inhibits trypsin and blocks
CC       voltage-gated potassium channels (Kv). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the venom Kunitz-type family. 02 (native)
CC       subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0CH75; -.
DR   BMRB; P0CH75; -.
DR   SMR; P0CH75; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0044562; P:envenomation resulting in negative regulation of voltage-gated potassium channel activity in another organism; IEA:UniProt.
DR   Gene3D; 4.10.410.10; -; 1.
DR   InterPro; IPR002223; Kunitz_BPTI.
DR   InterPro; IPR036880; Kunitz_BPTI_sf.
DR   Pfam; PF00014; Kunitz_BPTI; 1.
DR   SUPFAM; SSF57362; SSF57362; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Ion channel impairing toxin;
KW   Potassium channel impairing toxin; Protease inhibitor; Secreted;
KW   Serine protease inhibitor; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   PEPTIDE         1..>33
FT                   /note="Kunitz-type serine protease inhibitor hainantoxin
FT                   F7-25.66"
FT                   /id="PRO_0000401014"
FT   DOMAIN          4..>33
FT                   /note="BPTI/Kunitz inhibitor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   SITE            14..15
FT                   /note="Reactive bond for trypsin"
FT                   /evidence="ECO:0000250"
FT   NON_TER         33
SQ   SEQUENCE   33 AA;  3918 MW;  702B010AFE247B4C CRC64;
     IDTCRLPSDR GRCKASFERW YFNGRTCAKF IYG