VKT2A_HETCR
ID VKT2A_HETCR Reviewed; 56 AA.
AC P16344;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=PI-stichotoxin-Hcr2a {ECO:0000303|PubMed:22683676};
DE Short=PI-SHTX-Hcr2a {ECO:0000303|PubMed:22683676};
DE AltName: Full=Kunitz-type trypsin inhibitor IV {ECO:0000303|Ref.1};
DE Short=Jn-IV;
OS Heteractis crispa (Leathery sea anemone) (Radianthus macrodactylus).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Stichodactylidae; Heteractis.
OX NCBI_TaxID=175771;
RN [1]
RP PROTEIN SEQUENCE, FUNCTION, AND SUBCELLULAR LOCATION.
RA Zykova T.A., Vinokurov L.M., Markova L.F., Kozlovskaya E.P., Elyakov G.B.;
RT "Amino-acid sequence of trypsin inhibitor IV from Radiantis
RT macrodactylus.";
RL Bioorg. Khim. 11:293-301(1985).
RN [2]
RP NOMENCLATURE.
RX PubMed=22683676; DOI=10.1016/j.toxicon.2012.05.020;
RA Oliveira J.S., Fuentes-Silva D., King G.F.;
RT "Development of a rational nomenclature for naming peptide and protein
RT toxins from sea anemones.";
RL Toxicon 60:539-550(2012).
CC -!- FUNCTION: Serine protease inhibitor that acts on trypsin.
CC {ECO:0000269|Ref.1}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}. Nematocyst
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the venom Kunitz-type family. Sea anemone type 2
CC potassium channel toxin subfamily. {ECO:0000305}.
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DR PIR; JN0380; JN0380.
DR AlphaFoldDB; P16344; -.
DR SMR; P16344; -.
DR MEROPS; I02.061; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd00109; KU; 1.
DR Gene3D; 4.10.410.10; -; 1.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00131; KU; 1.
DR SUPFAM; SSF57362; SSF57362; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Nematocyst; Protease inhibitor;
KW Secreted; Serine protease inhibitor.
FT CHAIN 1..56
FT /note="PI-stichotoxin-Hcr2a"
FT /evidence="ECO:0000269|Ref.1"
FT /id="PRO_0000155418"
FT DOMAIN 4..54
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT SITE 14..15
FT /note="Reactive bond for trypsin"
FT /evidence="ECO:0000250|UniProtKB:P31713"
FT DISULFID 4..54
FT /evidence="ECO:0000250|UniProtKB:P31713"
FT DISULFID 13..37
FT /evidence="ECO:0000250|UniProtKB:P31713"
FT DISULFID 29..50
FT /evidence="ECO:0000250|UniProtKB:P31713"
SQ SEQUENCE 56 AA; 6172 MW; 68374D2025B841C0 CRC64;
GSICLEPKVV GPCTAYFPRF YFDSETGKCT PFIYGGCEGN SYVDEKLHAC RAICRA
