VKT2_DABSI
ID VKT2_DABSI Reviewed; 60 AA.
AC P00990;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Kunitz-type serine protease inhibitor 2;
DE AltName: Full=RVV-II;
DE AltName: Full=Venom basic protease inhibitor 2;
DE AltName: Full=Venom basic protease inhibitor II;
OS Daboia siamensis (Eastern Russel's viper) (Daboia russelii siamensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Viperinae; Daboia.
OX NCBI_TaxID=343250;
RN [1]
RP PROTEIN SEQUENCE, FUNCTION, AND DISULFIDE BONDS.
RC TISSUE=Venom;
RX PubMed=4436285;
RA Takahashi H., Iwanaga S., Kitagawa T., Hokama Y., Suzuki T.;
RT "Snake venom proteinase inhibitors. II. Chemical structure of inhibitor II
RT isolated from the venom of Russell's viper (Vipera russelli).";
RL J. Biochem. 76:721-733(1974).
CC -!- FUNCTION: Serine protease inhibitor. {ECO:0000269|PubMed:4436285}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- SIMILARITY: Belongs to the venom Kunitz-type family. {ECO:0000305}.
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DR AlphaFoldDB; P00990; -.
DR SMR; P00990; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd00109; KU; 1.
DR Gene3D; 4.10.410.10; -; 1.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00131; KU; 1.
DR SUPFAM; SSF57362; SSF57362; 1.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Protease inhibitor; Secreted;
KW Serine protease inhibitor.
FT CHAIN 1..60
FT /note="Kunitz-type serine protease inhibitor 2"
FT /id="PRO_0000155446"
FT DOMAIN 7..57
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT SITE 17..18
FT /note="Reactive bond for trypsin"
FT /evidence="ECO:0000250"
FT DISULFID 7..57
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031,
FT ECO:0000269|PubMed:4436285"
FT DISULFID 16..40
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031,
FT ECO:0000269|PubMed:4436285"
FT DISULFID 32..53
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031,
FT ECO:0000269|PubMed:4436285"
SQ SEQUENCE 60 AA; 6850 MW; 5A7DCE9554CE6EA2 CRC64;
HDRPTFCNLA PESGRCRGHL RRIYYNLESN KCKVFFYGGC GGNANNFETR DECRETCGGK
