VKT33_CYRSC
ID VKT33_CYRSC Reviewed; 88 AA.
AC B2ZBB8; P0DJ83;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 42.
DE RecName: Full=Kunitz-type U15-theraphotoxin-Hs1a;
DE Short=U15-TRTX-Hs1a;
DE AltName: Full=Huwentoxin-11g3 {ECO:0000303|PubMed:18590782};
DE Short=HW11g3 {ECO:0000303|PubMed:18590782};
DE AltName: Full=Kunitz-type serine protease inhibitor HWTX-XI-IS33 {ECO:0000303|PubMed:18923708};
DE Flags: Precursor;
OS Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Mygalomorphae; Theraphosidae; Cyriopagopus.
OX NCBI_TaxID=29017;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=18590782; DOI=10.1016/j.peptides.2008.06.001;
RA Jiang L., Chen J., Peng L., Zhang Y., Xiong X., Liang S.;
RT "Genomic organization and cloning of novel genes encoding toxin-like
RT peptides of three superfamilies from the spider Orinithoctonus huwena.";
RL Peptides 29:1679-1684(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RX PubMed=18923708; DOI=10.1371/journal.pone.0003414;
RA Yuan C.-H., He Q.-Y., Peng K., Diao J.-B., Jiang L.-P., Tang X.,
RA Liang S.-P.;
RT "Discovery of a distinct superfamily of Kunitz-type toxin (KTT) from
RT tarantulas.";
RL PLoS ONE 3:E3414-E3414(2008).
CC -!- FUNCTION: Dual-function toxin that inhibits both serine proteases and
CC voltage-gated potassium channels (Kv). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:18923708}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:18923708}.
CC -!- SIMILARITY: Belongs to the venom Kunitz-type family. 03 (sub-Kunitz)
CC subfamily. {ECO:0000305}.
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DR EMBL; EU635746; ACD01238.1; -; Genomic_DNA.
DR AlphaFoldDB; B2ZBB8; -.
DR SMR; B2ZBB8; -.
DR ArachnoServer; AS000481; U15-theraphotoxin-Hs1a.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0044562; P:envenomation resulting in negative regulation of voltage-gated potassium channel activity in another organism; IEA:UniProt.
DR CDD; cd00109; KU; 1.
DR Gene3D; 4.10.410.10; -; 1.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00131; KU; 1.
DR SUPFAM; SSF57362; SSF57362; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Ion channel impairing toxin;
KW Potassium channel impairing toxin; Protease inhibitor; Secreted;
KW Serine protease inhibitor; Signal; Toxin;
KW Voltage-gated potassium channel impairing toxin.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT PROPEP 28..33
FT /evidence="ECO:0000250"
FT /id="PRO_0000413840"
FT CHAIN 34..88
FT /note="Kunitz-type U15-theraphotoxin-Hs1a"
FT /id="PRO_0000413841"
FT DOMAIN 37..85
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT SITE 39
FT /note="May bind Kv1"
FT /evidence="ECO:0000250"
FT SITE 47..48
FT /note="Reactive bond for chymotrypsin"
FT /evidence="ECO:0000250"
FT DISULFID 37..85
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT DISULFID 60..81
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
SQ SEQUENCE 88 AA; 9779 MW; 52E7046769B2CF06 CRC64;
MGTARFLSAV LLLSVLLMVT FPALLSAEYH DGRVDICSLP SDSGDCLRFF EMWYFDGTTC
TKFVYGGYGG NDNRFPTEKA CMKRCAKA
