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CALC3_ONCKI
ID   CALC3_ONCKI             Reviewed;          32 AA.
AC   P01265;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Calcitonin-3;
OS   Oncorhynchus kisutch (Coho salmon) (Salmo kisutch).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8019;
RN   [1]
RP   PRELIMINARY PROTEIN SEQUENCE.
RA   Keutmann H.T., Lequin R.M., Habener J.F., Singer F.R., Niall H.D.,
RA   Potts J.T. Jr.;
RT   "Chemistry and physiology of the calcitonins: some recent advances.";
RL   (In) Taylor S. (eds.);
RL   Endocrinology 1971: proceedings of the third international symposium,
RL   pp.316-323, Heinemann Medical Books, London (1972).
RN   [2]
RP   SYNTHESIS, AND AMIDATION AT PRO-32.
RX   PubMed=4508400; DOI=10.1038/newbio240062a0;
RA   Pless J., Bauer W., Bossert H., Zehnder K., Guttmann S.;
RT   "Synthesis of two natural salmon calcitonins.";
RL   Nature New Biol. 240:62-63(1972).
CC   -!- FUNCTION: Causes a rapid but short-lived drop in the level of calcium
CC       and phosphate in blood by promoting the incorporation of those ions in
CC       the bones.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MISCELLANEOUS: Calcitonin 1 is less active than calcitonins 1 or 2.
CC       Only this species of salmon possesses calcitonin 3.
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   PIR; B01531; TCON3.
DR   AlphaFoldDB; P01265; -.
DR   SMR; P01265; -.
DR   Proteomes; UP000694557; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR021118; Calcitonin.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR018360; Calcitonin_CS.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   PANTHER; PTHR10505; PTHR10505; 1.
DR   PRINTS; PR00270; CALCITONINA.
DR   SMART; SM00113; CALCITONIN; 1.
DR   PROSITE; PS00258; CALCITONIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Hormone;
KW   Reference proteome; Secreted.
FT   PEPTIDE         1..32
FT                   /note="Calcitonin-3"
FT                   /id="PRO_0000044673"
FT   MOD_RES         32
FT                   /note="Proline amide"
FT                   /evidence="ECO:0000269|PubMed:4508400"
FT   DISULFID        1..7
FT                   /evidence="ECO:0000269|PubMed:4508400"
SQ   SEQUENCE   32 AA;  3419 MW;  B57A3D9AF807E7C2 CRC64;
     CSNLSTCMLG KLSQDLHKLQ TFPRTNTGAG VP
 
 
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