CALC3_ONCKI
ID CALC3_ONCKI Reviewed; 32 AA.
AC P01265;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Calcitonin-3;
OS Oncorhynchus kisutch (Coho salmon) (Salmo kisutch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Oncorhynchus.
OX NCBI_TaxID=8019;
RN [1]
RP PRELIMINARY PROTEIN SEQUENCE.
RA Keutmann H.T., Lequin R.M., Habener J.F., Singer F.R., Niall H.D.,
RA Potts J.T. Jr.;
RT "Chemistry and physiology of the calcitonins: some recent advances.";
RL (In) Taylor S. (eds.);
RL Endocrinology 1971: proceedings of the third international symposium,
RL pp.316-323, Heinemann Medical Books, London (1972).
RN [2]
RP SYNTHESIS, AND AMIDATION AT PRO-32.
RX PubMed=4508400; DOI=10.1038/newbio240062a0;
RA Pless J., Bauer W., Bossert H., Zehnder K., Guttmann S.;
RT "Synthesis of two natural salmon calcitonins.";
RL Nature New Biol. 240:62-63(1972).
CC -!- FUNCTION: Causes a rapid but short-lived drop in the level of calcium
CC and phosphate in blood by promoting the incorporation of those ions in
CC the bones.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- MISCELLANEOUS: Calcitonin 1 is less active than calcitonins 1 or 2.
CC Only this species of salmon possesses calcitonin 3.
CC -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR PIR; B01531; TCON3.
DR AlphaFoldDB; P01265; -.
DR SMR; P01265; -.
DR Proteomes; UP000694557; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR InterPro; IPR021118; Calcitonin.
DR InterPro; IPR021117; Calcitonin-like.
DR InterPro; IPR018360; Calcitonin_CS.
DR InterPro; IPR001693; Calcitonin_peptide-like.
DR PANTHER; PTHR10505; PTHR10505; 1.
DR PRINTS; PR00270; CALCITONINA.
DR SMART; SM00113; CALCITONIN; 1.
DR PROSITE; PS00258; CALCITONIN; 1.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Disulfide bond; Hormone;
KW Reference proteome; Secreted.
FT PEPTIDE 1..32
FT /note="Calcitonin-3"
FT /id="PRO_0000044673"
FT MOD_RES 32
FT /note="Proline amide"
FT /evidence="ECO:0000269|PubMed:4508400"
FT DISULFID 1..7
FT /evidence="ECO:0000269|PubMed:4508400"
SQ SEQUENCE 32 AA; 3419 MW; B57A3D9AF807E7C2 CRC64;
CSNLSTCMLG KLSQDLHKLQ TFPRTNTGAG VP