ID   CALCA_CANLF             Reviewed;         128 AA.
AC   Q9MYV1;
DT   10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Calcitonin gene-related peptide 1;
DE   AltName: Full=Alpha-type CGRP;
DE   AltName: Full=Calcitonin gene-related peptide I;
DE            Short=CGRP-I;
DE   Flags: Precursor;
GN   Name=CALCA; Synonyms=CALC, CCALCI;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10967131; DOI=10.1007/s003350010157;
RA   Wende S., Krempler A., Breen M., Brunnberg L., Brenig B.;
RT   "Molecular analysis and chromosomal assignment of the canine CALC-I/alpha-
RT   CGRP gene.";
RL   Mamm. Genome 11:736-740(2000).
RN   [2]
RP   PROTEIN SEQUENCE OF 26-50.
RC   TISSUE=Thyroid;
RX   PubMed=1758974; DOI=10.1016/0167-0115(91)90082-r;
RA   Mol J.A., Kwant M.M., Arnold I.C.J., Hazewinkel H.A.W.;
RT   "Elucidation of the sequence of canine (pro)-calcitonin. A molecular
RT   biological and protein chemical approach.";
RL   Regul. Pept. 35:189-195(1991).
CC   -!- FUNCTION: CGRP induces vasodilation. It dilates a variety of vessels
CC       including the coronary, cerebral and systemic vasculature. Its
CC       abundance in the CNS also points toward a neurotransmitter or
CC       neuromodulator role. It also elevates platelet cAMP (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Calcitonin-gene related peptide I;
CC         IsoId=Q9MYV1-1; Sequence=Displayed;
CC       Name=Calcitonin;
CC         IsoId=P41547-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   EMBL; AJ271090; CAB97487.1; -; Genomic_DNA.
DR   RefSeq; NP_001300719.1; NM_001313790.1. [Q9MYV1-1]
DR   RefSeq; NP_001300720.1; NM_001313791.1. [Q9MYV1-1]
DR   AlphaFoldDB; Q9MYV1; -.
DR   STRING; 9615.ENSCAFP00000046267; -.
DR   Ensembl; ENSCAFT00030047151; ENSCAFP00030041221; ENSCAFG00030025508. [Q9MYV1-1]
DR   Ensembl; ENSCAFT00040038162; ENSCAFP00040033271; ENSCAFG00040020572. [Q9MYV1-1]
DR   Ensembl; ENSCAFT00845041436; ENSCAFP00845032491; ENSCAFG00845023464. [Q9MYV1-1]
DR   GeneID; 403946; -.
DR   KEGG; cfa:403946; -.
DR   CTD; 796; -.
DR   VEuPathDB; HostDB:ENSCAFG00845023464; -.
DR   GeneTree; ENSGT00940000167380; -.
DR   HOGENOM; CLU_122444_1_0_1; -.
DR   OMA; QMKASAG; -.
DR   Reactome; R-CFA-418555; G alpha (s) signalling events.
DR   Reactome; R-CFA-419812; Calcitonin-like ligand receptors.
DR   Proteomes; UP000002254; Chromosome 21.
DR   Bgee; ENSCAFG00000008562; Expressed in spinal cord and 17 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031716; F:calcitonin receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR018360; Calcitonin_CS.
DR   InterPro; IPR015476; Calcitonin_gene-rel_peptide.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   PANTHER; PTHR10505; PTHR10505; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00817; CALCITONINB.
DR   SMART; SM00113; CALCITONIN; 1.
DR   PROSITE; PS00258; CALCITONIN; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW   Direct protein sequencing; Disulfide bond; Hormone; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000269|PubMed:1758974"
FT   PROPEP          26..80
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000004041"
FT   PEPTIDE         83..119
FT                   /note="Calcitonin gene-related peptide 1"
FT                   /id="PRO_0000004042"
FT   PROPEP          125..128
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000004043"
FT   REGION          63..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         119
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        84..89
FT                   /evidence="ECO:0000250"
FT   CONFLICT        45
FT                   /note="E -> K (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        49
FT                   /note="L -> N (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   128 AA;  13874 MW;  72331258DB8CB564 CRC64;
     MGLWKSSPFL AFSILVLCQA GGLQAAPFRS ALEGLPDPTA LSEKEGRLLL AALVKAYVQR
     KNELEQEQEQ ETEGSSITAQ KRSCNTATCV THRLAGLLSR SGGVVKNNFV PTNVGSEAFG
     RRRRDLRA