ID   CALCA_CHICK             Reviewed;         125 AA.
AC   P10286;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 2.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Calcitonin gene-related peptide;
DE            Short=CGRP;
DE   Flags: Precursor;
GN   Name=CALCA; Synonyms=CALC;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3666142; DOI=10.1016/0014-5793(87)80510-0;
RA   Minvielle S., Cressent M., Delehaye M.C., Segond N., Milhaud G.,
RA   Jullienne A., Moukhtar M.S., Lasmoles F.;
RT   "Sequence and expression of the chicken calcitonin gene.";
RL   FEBS Lett. 223:63-68(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 12-73.
RX   PubMed=4054101; DOI=10.1002/j.1460-2075.1985.tb03977.x;
RA   Lasmoles F., Jullienne A., Day F., Minvielle S., Milhaud G., Moukhtar M.S.;
RT   "Elucidation of the nucleotide sequence of chicken calcitonin mRNA: direct
RT   evidence for the expression of a lower vertebrate calcitonin-like gene in
RT   man and rat.";
RL   EMBO J. 4:2603-2607(1985).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 74-125.
RX   PubMed=3487468; DOI=10.1016/0014-5793(86)81425-9;
RA   Minvielle S., Cressent M., Lasmoles F., Jullienne A., Milhaud G.,
RA   Moukhtar M.S.;
RT   "Isolation and partial characterization of the calcitonin gene in a lower
RT   vertebrate. Predicted structure of avian calcitonin gene-related peptide.";
RL   FEBS Lett. 203:7-10(1986).
CC   -!- FUNCTION: CGRP induces vasodilation. It dilates a variety of vessels
CC       including the coronary, cerebral and systemic vasculature. Its
CC       abundance in the CNS also points toward a neurotransmitter or
CC       neuromodulator role.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Calcitonin-gene related peptide;
CC         IsoId=P10286-1; Sequence=Displayed;
CC       Name=Calcitonin;
CC         IsoId=P07660-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   EMBL; X06311; CAA29630.1; -; Genomic_DNA.
DR   EMBL; X06312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; X06314; CAA29633.1; -; Genomic_DNA.
DR   EMBL; X03012; CAA26796.1; ALT_TERM; mRNA.
DR   EMBL; D00007; BAA00006.1; -; Genomic_DNA.
DR   PIR; S00154; TCCHRP.
DR   AlphaFoldDB; P10286; -.
DR   SMR; P10286; -.
DR   VEuPathDB; HostDB:geneid_396256; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031716; F:calcitonin receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR018360; Calcitonin_CS.
DR   InterPro; IPR015476; Calcitonin_gene-rel_peptide.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   PANTHER; PTHR10505; PTHR10505; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00817; CALCITONINB.
DR   SMART; SM00113; CALCITONIN; 1.
DR   PROSITE; PS00258; CALCITONIN; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW   Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..77
FT                   /id="PRO_0000004074"
FT   PEPTIDE         80..116
FT                   /note="Calcitonin gene-related peptide"
FT                   /id="PRO_0000004075"
FT   PROPEP          122..125
FT                   /id="PRO_0000004076"
FT   MOD_RES         116
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        81..86
FT                   /evidence="ECO:0000250"
FT   CONFLICT        56
FT                   /note="D -> E (in Ref. 2; CAA26796)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   125 AA;  13729 MW;  E864A2C9AC111F80 CRC64;
     MVMLKISSFL AVYALVVCQM DSFQAAPVRP GLESITDRVT LSDYEARRLL NALVKDFIQM
     TAEELEQASE GNSVTAQKRA CNTATCVTHR LADFLSRSGG VGKNNFVPTN VGSKAFGRRR
     RSVQI