ID   CALCA_HORSE             Reviewed;         127 AA.
AC   Q9N0T2;
DT   10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Calcitonin gene-related peptide 1;
DE   AltName: Full=Alpha-type CGRP;
DE   AltName: Full=Calcitonin gene-related peptide I;
DE            Short=CGRP-I;
DE   Flags: Precursor;
GN   Name=CALCA; Synonyms=CALC;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12581884; DOI=10.1016/s0303-7207(02)00289-7;
RA   Toribio R.E., Kohn C.W., Leone G.W., Capen C.C., Rosol T.J.;
RT   "Molecular cloning and expression of equine calcitonin, calcitonin gene-
RT   related peptide-I, and calcitonin gene-related peptide-II.";
RL   Mol. Cell. Endocrinol. 199:119-128(2003).
CC   -!- FUNCTION: CGRP induces vasodilation. It dilates a variety of vessels
CC       including the coronary, cerebral and systemic vasculature. Its
CC       abundance in the CNS also points toward a neurotransmitter or
CC       neuromodulator role. It also elevates platelet cAMP (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Calcitonin-gene related peptide I;
CC         IsoId=Q9N0T2-1; Sequence=Displayed;
CC       Name=Calcitonin;
CC         IsoId=Q9N0V5-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   EMBL; AF257471; AAF70200.1; -; mRNA.
DR   RefSeq; NP_001075323.1; NM_001081854.3.
DR   RefSeq; NP_001078893.1; NM_001085424.1. [Q9N0T2-1]
DR   AlphaFoldDB; Q9N0T2; -.
DR   Ensembl; ENSECAT00000032452; ENSECAP00000035642; ENSECAG00000007825. [Q9N0T2-1]
DR   GeneID; 100033906; -.
DR   KEGG; ecb:100033906; -.
DR   CTD; 796; -.
DR   GeneTree; ENSGT00940000156267; -.
DR   OrthoDB; 1454612at2759; -.
DR   Proteomes; UP000002281; Chromosome 7.
DR   Bgee; ENSECAG00000007825; Expressed in testis and 9 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031716; F:calcitonin receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR015476; Calcitonin_gene-rel_peptide.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   PANTHER; PTHR10505; PTHR10505; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00817; CALCITONINB.
DR   SMART; SM00113; CALCITONIN; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW   Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..79
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000004047"
FT   CHAIN           82..118
FT                   /note="Calcitonin gene-related peptide 1"
FT                   /id="PRO_0000004048"
FT   PROPEP          124..127
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000004049"
FT   MOD_RES         118
FT                   /note="Serine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        83..88
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   127 AA;  13864 MW;  BA570B2AB49A6730 CRC64;
     MGFWKFSPFL PLSILVLYQV GIIQAAPFRS ALESLPDPAV LPEEESRLLL AALVKDYVQM
     KVRALEQEQE TGGASITAQK RSCNTASCLT HRLAGLLSSA GSMANSNLLP TEMGFKVSGR
     RRRDLQA