ID   VKT4_PSETT              Reviewed;          83 AA.
AC   Q90W98;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Kunitz-type serine protease inhibitor textilinin-4;
DE            Short=Txln-4;
DE   Flags: Precursor;
OS   Pseudonaja textilis textilis (Eastern brown snake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Acanthophiinae; Pseudonaja.
OX   NCBI_TaxID=169397;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=12406072; DOI=10.1046/j.1365-2141.2002.03878.x;
RA   Filippovich I., Sorokina N., Masci P.P., de Jersey J., Whitaker A.N.,
RA   Winzor D.J., Gaffney P.J., Lavin M.F.;
RT   "A family of textilinin genes, two of which encode proteins with
RT   antihaemorrhagic properties.";
RL   Br. J. Haematol. 119:376-384(2002).
CC   -!- FUNCTION: Serine protease inhibitor (By similarity). Does not inhibit
CC       plasmin, and does not reduce blood loss in the mouse tail vein blood
CC       loss model. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the venom Kunitz-type family. {ECO:0000305}.
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DR   EMBL; AF402327; AAK95522.1; -; mRNA.
DR   AlphaFoldDB; Q90W98; -.
DR   SMR; Q90W98; -.
DR   MEROPS; I02.052; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd00109; KU; 1.
DR   Gene3D; 4.10.410.10; -; 1.
DR   InterPro; IPR002223; Kunitz_BPTI.
DR   InterPro; IPR036880; Kunitz_BPTI_sf.
DR   InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR   Pfam; PF00014; Kunitz_BPTI; 1.
DR   PRINTS; PR00759; BASICPTASE.
DR   SMART; SM00131; KU; 1.
DR   SUPFAM; SSF57362; SSF57362; 1.
DR   PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR   PROSITE; PS50279; BPTI_KUNITZ_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Protease inhibitor; Secreted; Serine protease inhibitor;
KW   Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..83
FT                   /note="Kunitz-type serine protease inhibitor textilinin-4"
FT                   /id="PRO_0000376903"
FT   DOMAIN          31..81
FT                   /note="BPTI/Kunitz inhibitor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   SITE            41..42
FT                   /note="Reactive bond for trypsin"
FT                   /evidence="ECO:0000250"
FT   DISULFID        31..81
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        40..64
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        56..77
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
SQ   SEQUENCE   83 AA;  8983 MW;  3F28548146B48A9B CRC64;
     MSSGGLLLLL GLLTLWEVLT PVSSKDHPKF CELPADTGSC KGNVPRFYYN ADHHQCLKFI
     YGGCGGNANN FKTIEECKST CAA