VKT52_CYRHA
ID VKT52_CYRHA Reviewed; 71 AA.
AC P0DJ69;
DT 16-NOV-2011, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 1.
DT 03-AUG-2022, entry version 29.
DE RecName: Full=Kunitz-type serine protease inhibitor HNTX-852 {ECO:0000303|PubMed:18923708};
DE Flags: Precursor; Fragment;
OS Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Mygalomorphae; Theraphosidae; Haplopelma.
OX NCBI_TaxID=209901;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=18923708; DOI=10.1371/journal.pone.0003414;
RA Yuan C.-H., He Q.-Y., Peng K., Diao J.-B., Jiang L.-P., Tang X.,
RA Liang S.-P.;
RT "Discovery of a distinct superfamily of Kunitz-type toxin (KTT) from
RT tarantulas.";
RL PLoS ONE 3:E3414-E3414(2008).
CC -!- FUNCTION: Dual-function toxin that inhibits both serine proteases and
CC voltage-gated potassium channels (Kv). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:18923708}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:18923708}.
CC -!- SIMILARITY: Belongs to the venom Kunitz-type family. 03 (sub-Kunitz)
CC subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; P0DJ69; -.
DR SMR; P0DJ69; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0044562; P:envenomation resulting in negative regulation of voltage-gated potassium channel activity in another organism; IEA:UniProt.
DR CDD; cd00109; KU; 1.
DR Gene3D; 4.10.410.10; -; 1.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00131; KU; 1.
DR SUPFAM; SSF57362; SSF57362; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Ion channel impairing toxin;
KW Potassium channel impairing toxin; Protease inhibitor; Secreted;
KW Serine protease inhibitor; Signal; Toxin;
KW Voltage-gated potassium channel impairing toxin.
FT SIGNAL <1..22
FT /evidence="ECO:0000250"
FT CHAIN 23..71
FT /note="Kunitz-type serine protease inhibitor HNTX-852"
FT /id="PRO_0000413814"
FT DOMAIN 23..68
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT SITE 22
FT /note="May bind Kv1"
FT /evidence="ECO:0000250"
FT SITE 30..31
FT /note="Reactive bond for chymotrypsin"
FT /evidence="ECO:0000250"
FT DISULFID 20..68
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT DISULFID 43..64
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT NON_TER 1
SQ SEQUENCE 71 AA; 8079 MW; 19EAB4E84AE51E20 CRC64;
DPSGSPHIRI LPQETFEDIC RLPSDSGDCL RFFEMWYFDG TTCTKFVYGG YGGNDNRFPT
EKACMKRCAK A