CALCA_MOUSE
ID CALCA_MOUSE Reviewed; 128 AA.
AC Q99JA0;
DT 21-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Calcitonin gene-related peptide 1;
DE AltName: Full=Alpha-type CGRP;
DE AltName: Full=Calcitonin gene-related peptide I;
DE Short=CGRP-I;
DE Flags: Precursor;
GN Name=Calca; Synonyms=Calc;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Sarasa M., Catalan J., Aramayona J., Sorribas V.;
RT "Mouse CGRP precursor is highly homologous to that of the rat.";
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Sv;
RX PubMed=11761712; DOI=10.3109/10425170109047567;
RA Thomas P.M., Nasonkin I., Zhang H., Gagel R.F., Cote G.J.;
RT "Structure of the mouse calcitonin/calcitonin gene-related peptide alpha
RT and beta genes.";
RL DNA Seq. 12:131-135(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=18544925; DOI=10.1159/000124380;
RA Rezaeian A.H., Katafuchi T., Yoshizawa M., Hiraiwa N., Saito T.,
RA Nishibori M., Hamano K., Minamino N., Yasue H.;
RT "Genomic organization, expression and evolution of porcine CRSP1, 2, and
RT 3.";
RL Cytogenet. Genome Res. 121:41-49(2008).
CC -!- FUNCTION: CGRP induces vasodilation. It dilates a variety of vessels
CC including the coronary, cerebral and systemic vasculature. Its
CC abundance in the CNS also points toward a neurotransmitter or
CC neuromodulator role. It also elevates platelet cAMP (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Calcitonin-gene related peptide I;
CC IsoId=Q99JA0-1; Sequence=Displayed;
CC Name=Calcitonin;
CC IsoId=P70160-1; Sequence=External;
CC -!- TISSUE SPECIFICITY: Detected in nerve cells of cerebrum, hippocampus
CC and pons/midbrain in newborns, and only in nerve cells of pons/midbrain
CC in adult. {ECO:0000269|PubMed:18544925}.
CC -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR EMBL; AF330212; AAK06841.1; -; mRNA.
DR EMBL; AF325522; AAK18181.1; -; Genomic_DNA.
DR EMBL; AF325521; AAK18181.1; JOINED; Genomic_DNA.
DR EMBL; BC028771; AAH28771.1; -; mRNA.
DR CCDS; CCDS21762.1; -. [Q99JA0-1]
DR RefSeq; NP_001029126.1; NM_001033954.3. [Q99JA0-1]
DR RefSeq; NP_001276373.1; NM_001289444.1. [Q99JA0-1]
DR RefSeq; XP_011239962.1; XM_011241660.2. [Q99JA0-1]
DR AlphaFoldDB; Q99JA0; -.
DR DIP; DIP-60043N; -.
DR IntAct; Q99JA0; 2.
DR PRIDE; Q99JA0; -.
DR ProteomicsDB; 281760; -. [Q99JA0-1]
DR Antibodypedia; 3493; 1836 antibodies from 46 providers.
DR DNASU; 12310; -.
DR Ensembl; ENSMUST00000032906; ENSMUSP00000032906; ENSMUSG00000030669. [Q99JA0-1]
DR GeneID; 12310; -.
DR KEGG; mmu:12310; -.
DR UCSC; uc009jif.2; mouse. [Q99JA0-1]
DR CTD; 796; -.
DR MGI; MGI:2151253; Calca.
DR VEuPathDB; HostDB:ENSMUSG00000030669; -.
DR GeneTree; ENSGT00940000162876; -.
DR HOGENOM; CLU_122444_1_0_1; -.
DR OMA; QMKASAG; -.
DR BioGRID-ORCS; 12310; 0 hits in 74 CRISPR screens.
DR ChiTaRS; Calca; mouse.
DR Proteomes; UP000000589; Chromosome 7.
DR Bgee; ENSMUSG00000030669; Expressed in facial nucleus and 98 other tissues.
DR ExpressionAtlas; Q99JA0; baseline and differential.
DR Genevisible; Q99JA0; MM.
DR GO; GO:0030424; C:axon; IDA:MGI.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005576; C:extracellular region; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0043005; C:neuron projection; IDA:MGI.
DR GO; GO:0043025; C:neuronal cell body; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0043195; C:terminal bouton; IDA:MGI.
DR GO; GO:0031716; F:calcitonin receptor binding; IDA:MGI.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
DR GO; GO:0005102; F:signaling receptor binding; IDA:MGI.
DR GO; GO:0007190; P:activation of adenylate cyclase activity; IDA:MGI.
DR GO; GO:0032147; P:activation of protein kinase activity; ISO:MGI.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IGI:MGI.
DR GO; GO:0097647; P:amylin receptor signaling pathway; ISO:MGI.
DR GO; GO:0001984; P:artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure; IMP:MGI.
DR GO; GO:1990408; P:calcitonin gene-related peptide receptor signaling pathway; ISO:MGI.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IGI:MGI.
DR GO; GO:1990090; P:cellular response to nerve growth factor stimulus; IDA:MGI.
DR GO; GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; IMP:MGI.
DR GO; GO:0007566; P:embryo implantation; ISO:MGI.
DR GO; GO:0043542; P:endothelial cell migration; ISO:MGI.
DR GO; GO:0001935; P:endothelial cell proliferation; ISO:MGI.
DR GO; GO:0007631; P:feeding behavior; IDA:MGI.
DR GO; GO:0002031; P:G protein-coupled receptor internalization; ISO:MGI.
DR GO; GO:0006954; P:inflammatory response; IDA:MGI.
DR GO; GO:0007159; P:leukocyte cell-cell adhesion; ISO:MGI.
DR GO; GO:0002548; P:monocyte chemotaxis; ISO:MGI.
DR GO; GO:0045776; P:negative regulation of blood pressure; IMP:MGI.
DR GO; GO:0045779; P:negative regulation of bone resorption; ISO:MGI.
DR GO; GO:0010523; P:negative regulation of calcium ion transport into cytosol; ISO:MGI.
DR GO; GO:0030279; P:negative regulation of ossification; IMP:MGI.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISO:MGI.
DR GO; GO:0045986; P:negative regulation of smooth muscle contraction; IDA:MGI.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0001976; P:nervous system process involved in regulation of systemic arterial blood pressure; ISA:MGI.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IDA:MGI.
DR GO; GO:0001503; P:ossification; IMP:MGI.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
DR GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; ISO:MGI.
DR GO; GO:0032730; P:positive regulation of interleukin-1 alpha production; ISO:MGI.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; ISO:MGI.
DR GO; GO:0045651; P:positive regulation of macrophage differentiation; ISO:MGI.
DR GO; GO:0006468; P:protein phosphorylation; ISO:MGI.
DR GO; GO:0031623; P:receptor internalization; ISO:MGI.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; ISO:MGI.
DR GO; GO:0008016; P:regulation of heart contraction; ISO:MGI.
DR GO; GO:0009408; P:response to heat; IMP:MGI.
DR GO; GO:0048265; P:response to pain; IMP:MGI.
DR GO; GO:0006939; P:smooth muscle contraction; IDA:MGI.
DR GO; GO:0048240; P:sperm capacitation; ISA:MGI.
DR GO; GO:0001944; P:vasculature development; ISO:MGI.
DR GO; GO:0042311; P:vasodilation; ISO:MGI.
DR InterPro; IPR021117; Calcitonin-like.
DR InterPro; IPR021116; Calcitonin/adrenomedullin.
DR InterPro; IPR018360; Calcitonin_CS.
DR InterPro; IPR015476; Calcitonin_gene-rel_peptide.
DR InterPro; IPR001693; Calcitonin_peptide-like.
DR PANTHER; PTHR10505; PTHR10505; 1.
DR Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR PRINTS; PR00817; CALCITONINB.
DR SMART; SM00113; CALCITONIN; 1.
DR PROSITE; PS00258; CALCITONIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT PROPEP 26..80
FT /evidence="ECO:0000250"
FT /id="PRO_0000004059"
FT PEPTIDE 83..119
FT /note="Calcitonin gene-related peptide 1"
FT /id="PRO_0000004060"
FT PROPEP 125..128
FT /evidence="ECO:0000250"
FT /id="PRO_0000004061"
FT MOD_RES 119
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000250"
FT DISULFID 84..89
FT /evidence="ECO:0000250"
SQ SEQUENCE 128 AA; 14065 MW; 83BB0E36C8B4239E CRC64;
MGFLKFSPFL VVSILLLYQA CSLQAVPLRS ILESSPGMAT LSEEEVRLLA ALVQDYMQMK
ARELEQEEEQ EAEGSSVTAQ KRSCNTATCV THRLAGLLSR SGGVVKDNFV PTNVGSEAFG
RRRRDLQA
