ID   CALCA_PIG               Reviewed;          37 AA.
AC   P30880;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Calcitonin gene-related peptide;
DE            Short=CGRP;
GN   Name=CALCA; Synonyms=CALC;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT PHE-37.
RX   PubMed=3494209; DOI=10.1016/0143-4179(87)90034-5;
RA   Kimura S., Sugita Y., Kanazawa I., Saito A., Goto K.;
RT   "Isolation and amino acid sequence of calcitonin gene related peptide from
RT   porcine spinal cord.";
RL   Neuropeptides 9:75-82(1987).
CC   -!- FUNCTION: CGRP induces vasodilation. It dilates a variety of vessels
CC       including the coronary, cerebral and systemic vasculature. Its
CC       abundance in the CNS also points toward a neurotransmitter or
CC       neuromodulator role.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   AlphaFoldDB; P30880; -.
DR   SMR; P30880; -.
DR   HOGENOM; CLU_122444_1_0_1; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031716; F:calcitonin receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:UniProtKB.
DR   GO; GO:1990408; P:calcitonin gene-related peptide receptor signaling pathway; IDA:UniProtKB.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR018360; Calcitonin_CS.
DR   InterPro; IPR015476; Calcitonin_gene-rel_peptide.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   PANTHER; PTHR10505; PTHR10505; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00817; CALCITONINB.
DR   SMART; SM00113; CALCITONIN; 1.
DR   PROSITE; PS00258; CALCITONIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Hormone;
KW   Reference proteome; Secreted.
FT   PEPTIDE         1..37
FT                   /note="Calcitonin gene-related peptide"
FT                   /id="PRO_0000044667"
FT   MOD_RES         37
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:3494209"
FT   DISULFID        2..7
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   37 AA;  3814 MW;  04CDEB8D248B64BA CRC64;
     SCNTATCVTH RLAGLLSRSG GMVKSNFVPT DVGSEAF