CALCA_RAT
ID CALCA_RAT Reviewed; 128 AA.
AC P01256;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1988, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Calcitonin gene-related peptide 1;
DE AltName: Full=Alpha-type CGRP;
DE AltName: Full=Calcitonin gene-related peptide I;
DE Short=CGRP-I;
DE Flags: Precursor;
GN Name=Calca; Synonyms=Calc;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=3872459; DOI=10.1073/pnas.82.7.1994;
RA Jonas V., Lin C.R., Kawashima E., Semon D., Swanson L.W., Mermod J.-J.,
RA Evans R.M., Rosenfeld M.G.;
RT "Alternative RNA processing events in human calcitonin/calcitonin gene-
RT related peptide gene expression.";
RL Proc. Natl. Acad. Sci. U.S.A. 82:1994-1998(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=6283379; DOI=10.1038/298240a0;
RA Amara S.G., Jonas V., Rosenfeld M.G., Ong E.S., Evans R.M.;
RT "Alternative RNA processing in calcitonin gene expression generates mRNAs
RT encoding different polypeptide products.";
RL Nature 298:240-244(1982).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2994212; DOI=10.1126/science.2994212;
RA Amara S.G., Arriza J.L., Leff S.E., Swanson L.W., Evans R.M.,
RA Rosenfeld M.G.;
RT "Expression in brain of a messenger RNA encoding a novel neuropeptide
RT homologous to calcitonin gene-related peptide.";
RL Science 229:1094-1097(1985).
CC -!- FUNCTION: CGRP induces vasodilation. It dilates a variety of vessels
CC including the coronary, cerebral and systemic vasculature. Its
CC abundance in the CNS also points toward a neurotransmitter or
CC neuromodulator role.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Calcitonin-gene related peptide I;
CC IsoId=P01256-1; Sequence=Displayed;
CC Name=Calcitonin;
CC IsoId=P01257-1; Sequence=External;
CC -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR EMBL; L29188; AAB59682.1; -; Genomic_DNA.
DR EMBL; L00109; AAB59682.1; JOINED; Genomic_DNA.
DR EMBL; L00110; AAB59682.1; JOINED; Genomic_DNA.
DR EMBL; V01231; CAA24541.1; -; mRNA.
DR EMBL; M11597; AAA40847.1; -; mRNA.
DR PIR; A01524; TCRTR.
DR PIR; B44173; B44173.
DR RefSeq; NP_001029127.1; NM_001033955.1.
DR RefSeq; NP_001029128.1; NM_001033956.1.
DR AlphaFoldDB; P01256; -.
DR BioGRID; 246427; 3.
DR BindingDB; P01256; -.
DR ChEMBL; CHEMBL5735; -.
DR ABCD; P01256; 1 sequenced antibody.
DR GeneID; 24241; -.
DR KEGG; rno:24241; -.
DR CTD; 796; -.
DR RGD; 2254; Calca.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0030424; C:axon; IDA:RGD.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005576; C:extracellular region; ISO:RGD.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0043005; C:neuron projection; ISO:RGD.
DR GO; GO:0043025; C:neuronal cell body; IDA:RGD.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0043195; C:terminal bouton; ISO:RGD.
DR GO; GO:0031716; F:calcitonin receptor binding; ISO:RGD.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0005184; F:neuropeptide hormone activity; TAS:RGD.
DR GO; GO:0044877; F:protein-containing complex binding; ISO:RGD.
DR GO; GO:0005102; F:signaling receptor binding; ISO:RGD.
DR GO; GO:0007190; P:activation of adenylate cyclase activity; ISO:RGD.
DR GO; GO:0032147; P:activation of protein kinase activity; ISO:RGD.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISO:RGD.
DR GO; GO:0007568; P:aging; IEP:RGD.
DR GO; GO:0097647; P:amylin receptor signaling pathway; ISO:RGD.
DR GO; GO:0001984; P:artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure; ISO:RGD.
DR GO; GO:1990408; P:calcitonin gene-related peptide receptor signaling pathway; ISO:RGD.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; ISO:RGD.
DR GO; GO:1990090; P:cellular response to nerve growth factor stimulus; IEP:RGD.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IEP:RGD.
DR GO; GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; ISO:RGD.
DR GO; GO:0007566; P:embryo implantation; ISO:RGD.
DR GO; GO:0043542; P:endothelial cell migration; ISO:RGD.
DR GO; GO:0001935; P:endothelial cell proliferation; ISO:RGD.
DR GO; GO:0007631; P:feeding behavior; ISO:RGD.
DR GO; GO:0002031; P:G protein-coupled receptor internalization; ISO:RGD.
DR GO; GO:0006954; P:inflammatory response; IEP:RGD.
DR GO; GO:0007159; P:leukocyte cell-cell adhesion; ISO:RGD.
DR GO; GO:0002548; P:monocyte chemotaxis; ISO:RGD.
DR GO; GO:0045776; P:negative regulation of blood pressure; IMP:RGD.
DR GO; GO:0045779; P:negative regulation of bone resorption; ISO:RGD.
DR GO; GO:0010523; P:negative regulation of calcium ion transport into cytosol; ISO:RGD.
DR GO; GO:0030279; P:negative regulation of ossification; ISO:RGD.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISO:RGD.
DR GO; GO:0045986; P:negative regulation of smooth muscle contraction; IMP:RGD.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0007218; P:neuropeptide signaling pathway; ISO:RGD.
DR GO; GO:0045785; P:positive regulation of cell adhesion; ISO:RGD.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:RGD.
DR GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; ISO:RGD.
DR GO; GO:0032730; P:positive regulation of interleukin-1 alpha production; ISO:RGD.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; ISO:RGD.
DR GO; GO:0045651; P:positive regulation of macrophage differentiation; ISO:RGD.
DR GO; GO:0006468; P:protein phosphorylation; ISO:RGD.
DR GO; GO:0031623; P:receptor internalization; ISO:RGD.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; ISO:RGD.
DR GO; GO:0008016; P:regulation of heart contraction; IDA:RGD.
DR GO; GO:0009408; P:response to heat; ISO:RGD.
DR GO; GO:0048265; P:response to pain; ISO:RGD.
DR GO; GO:0001944; P:vasculature development; ISO:RGD.
DR GO; GO:0042311; P:vasodilation; IDA:RGD.
DR InterPro; IPR021117; Calcitonin-like.
DR InterPro; IPR021116; Calcitonin/adrenomedullin.
DR InterPro; IPR018360; Calcitonin_CS.
DR InterPro; IPR015476; Calcitonin_gene-rel_peptide.
DR InterPro; IPR001693; Calcitonin_peptide-like.
DR PANTHER; PTHR10505; PTHR10505; 1.
DR Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR PRINTS; PR00817; CALCITONINB.
DR SMART; SM00113; CALCITONIN; 1.
DR PROSITE; PS00258; CALCITONIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT PROPEP 26..80
FT /id="PRO_0000004065"
FT PEPTIDE 83..119
FT /note="Calcitonin gene-related peptide 1"
FT /id="PRO_0000004066"
FT PROPEP 125..128
FT /id="PRO_0000004067"
FT MOD_RES 119
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000250"
FT DISULFID 84..89
FT /evidence="ECO:0000250"
FT CONFLICT 40
FT /note="Missing (in Ref. 2; AAB59682/CAA24541 and 3;
FT AAA40847)"
FT /evidence="ECO:0000305"
FT CONFLICT 51
FT /note="Missing (in Ref. 2; AAB59682/CAA24541 and 3;
FT AAA40847)"
FT /evidence="ECO:0000305"
FT CONFLICT 70
FT /note="Q -> EEQ (in Ref. 2; AAB59682/CAA24541 and 3;
FT AAA40847)"
FT /evidence="ECO:0000305"
FT CONFLICT 99
FT /note="S -> R (in Ref. 3; AAA40847)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 128 AA; 13948 MW; 75D14869C17078D3 CRC64;
MGFLKFSPFL VVSILLLYQA CGLQAVPLRS TLESSPGMAA TLSEEEARLL LAALVQNYMQ
MKVRELEQEQ EAEGSSVTAQ KRSCNTATCV THRLAGLLSR SGGVVKDNFV PTNVGSEAFG
RRRRDLQA
