ID   CALCA_SHEEP             Reviewed;          37 AA.
AC   P30881;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Calcitonin gene-related peptide;
DE            Short=CGRP;
GN   Name=CALCA; Synonyms=CALC;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT PHE-37.
RC   TISSUE=Hypothalamus;
RX   PubMed=1417824; DOI=10.1016/0006-291x(92)90468-z;
RA   Miyata A., Jiang L., Minamino N., Arimura A.;
RT   "Identification of calcitonin gene related peptide in ovine hypothalamic
RT   extract.";
RL   Biochem. Biophys. Res. Commun. 187:1474-1479(1992).
CC   -!- FUNCTION: CGRP induces vasodilation. It dilates a variety of vessels
CC       including the coronary, cerebral and systemic vasculature. Its
CC       abundance in the CNS also points toward a neurotransmitter or
CC       neuromodulator role.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   PIR; JH0709; JH0709.
DR   AlphaFoldDB; P30881; -.
DR   SMR; P30881; -.
DR   STRING; 9940.ENSOARP00000022799; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR018360; Calcitonin_CS.
DR   InterPro; IPR015476; Calcitonin_gene-rel_peptide.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   PANTHER; PTHR10505; PTHR10505; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00817; CALCITONINB.
DR   SMART; SM00113; CALCITONIN; 1.
DR   PROSITE; PS00258; CALCITONIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Hormone;
KW   Reference proteome; Secreted.
FT   PEPTIDE         1..37
FT                   /note="Calcitonin gene-related peptide"
FT                   /id="PRO_0000044668"
FT   MOD_RES         37
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:1417824"
FT   DISULFID        2..7
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   37 AA;  3780 MW;  F5DDF64D248B6A47 CRC64;
     SCNTATCVTH RLAGLLSRSG GVVKSNFVPT NVGSQAF