VKTC8_DABSI
ID VKTC8_DABSI Reviewed; 23 AA.
AC P85039;
DT 14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 25-MAY-2022, entry version 13.
DE RecName: Full=Kunitz-type serine protease inhibitor C8;
DE AltName: Full=BPTI-8 {ECO:0000303|Ref.1};
DE AltName: Full=Chymotrypsin inhibitor 8;
DE AltName: Full=Chymotrypsin inhibitor B8 {ECO:0000303|Ref.1};
DE AltName: Full=Chymotrypsin inhibitor C8 {ECO:0000303|Ref.1};
DE Flags: Fragment;
OS Daboia siamensis (Eastern Russel's viper) (Daboia russelii siamensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Viperinae; Daboia.
OX NCBI_TaxID=343250;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC STRAIN=Burma {ECO:0000269|Ref.1}, and China {ECO:0000269|Ref.1};
RC TISSUE=Venom {ECO:0000269|Ref.1};
RA Guo C.T.;
RT "Molecular analysis of the bioactive components in snake venoms.";
RL Submitted (NOV-2006) to UniProtKB.
CC -!- FUNCTION: Serine protease inhibitor that inhibits chymotrypsin.
CC {ECO:0000269|Ref.1}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
CC -!- SIMILARITY: Belongs to the venom Kunitz-type family. {ECO:0000305}.
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DR AlphaFoldDB; P85039; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Protease inhibitor; Secreted;
KW Serine protease inhibitor.
FT PEPTIDE 1..>23
FT /note="Kunitz-type serine protease inhibitor C8"
FT /id="PRO_0000414613"
FT DOMAIN 7..>23
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT SITE 17..18
FT /note="Reactive bond for chymotrypsin"
FT /evidence="ECO:0000250"
FT DISULFID 7..?
FT /evidence="ECO:0000250|UniProtKB:P00992,
FT ECO:0000255|PROSITE-ProRule:PRU00031"
FT DISULFID 16..?
FT /evidence="ECO:0000250|UniProtKB:P00992,
FT ECO:0000255|PROSITE-ProRule:PRU00031"
FT NON_TER 23
FT /evidence="ECO:0000303|Ref.1"
SQ SEQUENCE 23 AA; 2691 MW; 74A097638601B0DB CRC64;
HDRPKFCYLP ADPGECLAHM RSF