ID   CALCB_HORSE             Reviewed;         129 AA.
AC   Q9N0T3;
DT   10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Calcitonin gene-related peptide 2;
DE   AltName: Full=Beta-type CGRP;
DE   AltName: Full=Calcitonin gene-related peptide II;
DE            Short=CGRP-II;
DE   Flags: Precursor;
GN   Name=CALCB;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12581884; DOI=10.1016/s0303-7207(02)00289-7;
RA   Toribio R.E., Kohn C.W., Leone G.W., Capen C.C., Rosol T.J.;
RT   "Molecular cloning and expression of equine calcitonin, calcitonin gene-
RT   related peptide-I, and calcitonin gene-related peptide-II.";
RL   Mol. Cell. Endocrinol. 199:119-128(2003).
CC   -!- FUNCTION: CGRP induces vasodilation. It dilates a variety of vessels
CC       including the coronary, cerebral and systemic vasculature. Its
CC       abundance in the CNS also points toward a neurotransmitter or
CC       neuromodulator role (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   EMBL; AF257470; AAF70199.1; -; mRNA.
DR   RefSeq; NP_001075397.1; NM_001081928.2.
DR   AlphaFoldDB; Q9N0T3; -.
DR   STRING; 9796.ENSECAP00000053164; -.
DR   PaxDb; Q9N0T3; -.
DR   PRIDE; Q9N0T3; -.
DR   GeneID; 100034126; -.
DR   KEGG; ecb:100034126; -.
DR   CTD; 797; -.
DR   HOGENOM; CLU_122444_1_0_1; -.
DR   InParanoid; Q9N0T3; -.
DR   OMA; QMKASAG; -.
DR   OrthoDB; 1547206at2759; -.
DR   TreeFam; TF333069; -.
DR   Proteomes; UP000002281; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031716; F:calcitonin receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR018360; Calcitonin_CS.
DR   InterPro; IPR015476; Calcitonin_gene-rel_peptide.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   PANTHER; PTHR10505; PTHR10505; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00817; CALCITONINB.
DR   SMART; SM00113; CALCITONIN; 1.
DR   PROSITE; PS00258; CALCITONIN; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..81
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000004083"
FT   PEPTIDE         84..120
FT                   /note="Calcitonin gene-related peptide 2"
FT                   /id="PRO_0000004084"
FT   PROPEP          126..129
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000004085"
FT   MOD_RES         120
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        85..90
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   129 AA;  13925 MW;  97C2C7AC713ABD9B CRC64;
     MGFGKPSSFL AFSILVLCQA GSLQAQPLRS SLESLPDPAA LSEKEGRLLL AALVKAYVQR
     KTNELEQEQE QEMEGSSLTA QKRSCNTATC VTHRLAGLLS RSGGVVKSNF VPTDVGSEAF
     GRRRRDLQA