ID   CALCB_MOUSE             Reviewed;         130 AA.
AC   Q99MP3;
DT   21-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Calcitonin gene-related peptide 2;
DE   AltName: Full=Beta-type CGRP;
DE   AltName: Full=Calcitonin gene-related peptide II;
DE            Short=CGRP-II;
DE   Flags: Precursor;
GN   Name=Calcb;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=129/Sv;
RX   PubMed=11761712; DOI=10.3109/10425170109047567;
RA   Thomas P.M., Nasonkin I., Zhang H., Gagel R.F., Cote G.J.;
RT   "Structure of the mouse calcitonin/calcitonin gene-related peptide alpha
RT   and beta genes.";
RL   DNA Seq. 12:131-135(2001).
RN   [2]
RP   TISSUE SPECIFICITY.
RX   PubMed=18544925; DOI=10.1159/000124380;
RA   Rezaeian A.H., Katafuchi T., Yoshizawa M., Hiraiwa N., Saito T.,
RA   Nishibori M., Hamano K., Minamino N., Yasue H.;
RT   "Genomic organization, expression and evolution of porcine CRSP1, 2, and
RT   3.";
RL   Cytogenet. Genome Res. 121:41-49(2008).
CC   -!- FUNCTION: CGRP induces vasodilation. It dilates a variety of vessels
CC       including the coronary, cerebral and systemic vasculature. Its
CC       abundance in the CNS also points toward a neurotransmitter or
CC       neuromodulator role (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Detected in nerve cells of cerebrum, hippocampus
CC       and pons/midbrain in newborns, and only in nerve cells of pons/midbrain
CC       in adult. {ECO:0000269|PubMed:18544925}.
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   EMBL; AF325526; AAK16431.1; -; Genomic_DNA.
DR   EMBL; AF325524; AAK16431.1; JOINED; Genomic_DNA.
DR   CCDS; CCDS21764.1; -.
DR   AlphaFoldDB; Q99MP3; -.
DR   STRING; 10090.ENSMUSP00000032902; -.
DR   PhosphoSitePlus; Q99MP3; -.
DR   PaxDb; Q99MP3; -.
DR   PRIDE; Q99MP3; -.
DR   ProteomicsDB; 273904; -.
DR   MGI; MGI:2151254; Calcb.
DR   eggNOG; ENOG502SQMP; Eukaryota.
DR   InParanoid; Q99MP3; -.
DR   PhylomeDB; Q99MP3; -.
DR   Reactome; R-MMU-418555; G alpha (s) signalling events.
DR   Reactome; R-MMU-419812; Calcitonin-like ligand receptors.
DR   PRO; PR:Q99MP3; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q99MP3; protein.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031716; F:calcitonin receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR018360; Calcitonin_CS.
DR   InterPro; IPR015476; Calcitonin_gene-rel_peptide.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   PANTHER; PTHR10505; PTHR10505; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00817; CALCITONINB.
DR   SMART; SM00113; CALCITONIN; 1.
DR   PROSITE; PS00258; CALCITONIN; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   PROPEP          27..82
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000004089"
FT   PEPTIDE         84..120
FT                   /note="Calcitonin gene-related peptide 2"
FT                   /id="PRO_0000004090"
FT   PROPEP          127..130
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000004091"
FT   MOD_RES         120
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        85..90
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   130 AA;  14623 MW;  97299244E8F6C536 CRC64;
     MDFWKFFPFL ALSTIWVLCL ASSLQAAPFR SALESSLDLG TLGDQEKHLL LAALMQDYEQ
     MKARKLEQEE QETKGSRVTA QKRSCNTATC VTHRLADLLS RSGGVLKDNF VPTDVGSEAF
     GRRRRRDLQA