ID   CALCB_RAT               Reviewed;         134 AA.
AC   P10093;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 121.
DE   RecName: Full=Calcitonin gene-related peptide 2;
DE   AltName: Full=Beta-type CGRP;
DE   AltName: Full=Calcitonin gene-related peptide II;
DE            Short=CGRP-II;
DE   Flags: Precursor;
GN   Name=Calcb;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2994212; DOI=10.1126/science.2994212;
RA   Amara S.G., Arriza J.L., Leff S.E., Swanson L.W., Evans R.M.,
RA   Rosenfeld M.G.;
RT   "Expression in brain of a messenger RNA encoding a novel neuropeptide
RT   homologous to calcitonin gene-related peptide.";
RL   Science 229:1094-1097(1985).
CC   -!- FUNCTION: CGRP induces vasodilation. It dilates a variety of vessels
CC       including the coronary, cerebral and systemic vasculature. Its
CC       abundance in the CNS also points toward a neurotransmitter or
CC       neuromodulator role.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   EMBL; M11596; AAA40850.1; -; mRNA.
DR   PIR; A44173; A44173.
DR   RefSeq; NP_612522.1; NM_138513.1.
DR   AlphaFoldDB; P10093; -.
DR   STRING; 10116.ENSRNOP00000014764; -.
DR   iPTMnet; P10093; -.
DR   PhosphoSitePlus; P10093; -.
DR   PaxDb; P10093; -.
DR   ABCD; P10093; 1 sequenced antibody.
DR   GeneID; 171519; -.
DR   KEGG; rno:171519; -.
DR   UCSC; RGD:620997; rat.
DR   CTD; 797; -.
DR   RGD; 620997; Calcb.
DR   eggNOG; ENOG502SQMP; Eukaryota.
DR   InParanoid; P10093; -.
DR   OrthoDB; 1547206at2759; -.
DR   PhylomeDB; P10093; -.
DR   Reactome; R-RNO-419812; Calcitonin-like ligand receptors.
DR   PRO; PR:P10093; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031716; F:calcitonin receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR018360; Calcitonin_CS.
DR   InterPro; IPR015476; Calcitonin_gene-rel_peptide.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   PANTHER; PTHR10505; PTHR10505; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00817; CALCITONINB.
DR   SMART; SM00113; CALCITONIN; 1.
DR   PROSITE; PS00258; CALCITONIN; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   PROPEP          27..86
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000004092"
FT   PEPTIDE         89..125
FT                   /note="Calcitonin gene-related peptide 2"
FT                   /id="PRO_0000004093"
FT   PROPEP          131..134
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000004094"
FT   REGION          65..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..91
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         125
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        90..95
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   134 AA;  14965 MW;  BF6CAFB87A489B38 CRC64;
     MDFWKFFPFL ALSSMWVLCL ASSLQAAPFR SALESSLDLG TLSDQEKHLL LAALIQDYEQ
     KARKLEQEEQ ETEGSRKGSS SSVISQKRSC NTATCVTHRL AGLLRRSGGV VKDNFVPTNV
     GSKAFGRRRR DLRV