位置:首页 > 蛋白库 > CALCR_MOUSE
CALCR_MOUSE
ID   CALCR_MOUSE             Reviewed;         533 AA.
AC   Q60755; F6X7J4; Q3UUL9; Q8CAB0;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2013, sequence version 2.
DT   03-AUG-2022, entry version 161.
DE   RecName: Full=Calcitonin receptor {ECO:0000305};
DE            Short=CT-R;
DE   Flags: Precursor;
GN   Name=Calcr {ECO:0000312|MGI:MGI:101950};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   STRAIN=BALB/cJ; TISSUE=Brain;
RX   PubMed=7988453; DOI=10.1210/endo.135.6.7988453;
RA   Yamin M., Gorn A.H., Flannery M.R., Jenkins N.A., Gilbert D.J.,
RA   Copeland N.G., Tapp D.R., Krane S.M., Goldring S.R.;
RT   "Cloning and characterization of a mouse brain calcitonin receptor
RT   complementary deoxyribonucleic acid and mapping of the calcitonin receptor
RT   gene.";
RL   Endocrinology 135:2635-2643(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=C57BL/6J; TISSUE=Diencephalon, and Hypothalamus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: This is a receptor for calcitonin. The activity of this
CC       receptor is mediated by G proteins which activate adenylyl cyclase. The
CC       calcitonin receptor is thought to couple to the heterotrimeric
CC       guanosine triphosphate-binding protein that is sensitive to cholera
CC       toxin.
CC   -!- SUBUNIT: Interacts with GPRASP2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q60755-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q60755-2; Sequence=VSP_053294;
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA69521.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U18542; AAA69521.1; ALT_INIT; mRNA.
DR   EMBL; AK039161; BAC30261.1; -; mRNA.
DR   EMBL; AK162391; BAE36888.1; -; mRNA.
DR   EMBL; AK133983; BAE21967.1; -; mRNA.
DR   EMBL; AK138275; BAE23606.1; -; mRNA.
DR   EMBL; AC066688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC161368; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466533; EDL13991.1; -; Genomic_DNA.
DR   EMBL; CH466533; EDL13992.1; -; Genomic_DNA.
DR   EMBL; BC119232; AAI19233.1; -; mRNA.
DR   EMBL; BC119272; AAI19273.1; -; mRNA.
DR   CCDS; CCDS39416.1; -. [Q60755-2]
DR   CCDS; CCDS39417.1; -. [Q60755-1]
DR   PIR; I49154; I49154.
DR   RefSeq; NP_001036190.1; NM_001042725.1. [Q60755-2]
DR   RefSeq; NP_031614.2; NM_007588.2. [Q60755-1]
DR   RefSeq; XP_006505035.1; XM_006504972.1.
DR   RefSeq; XP_006505036.1; XM_006504973.2.
DR   AlphaFoldDB; Q60755; -.
DR   SMR; Q60755; -.
DR   ComplexPortal; CPX-3235; Amylin receptor 1 complex.
DR   ComplexPortal; CPX-3236; Amylin receptor 2 complex.
DR   ComplexPortal; CPX-3237; Amylin receptor 3 complex.
DR   STRING; 10090.ENSMUSP00000075070; -.
DR   GlyGen; Q60755; 4 sites.
DR   iPTMnet; Q60755; -.
DR   PhosphoSitePlus; Q60755; -.
DR   PaxDb; Q60755; -.
DR   PRIDE; Q60755; -.
DR   Antibodypedia; 15689; 424 antibodies from 25 providers.
DR   DNASU; 12311; -.
DR   Ensembl; ENSMUST00000075644; ENSMUSP00000075070; ENSMUSG00000023964. [Q60755-1]
DR   Ensembl; ENSMUST00000115622; ENSMUSP00000111285; ENSMUSG00000023964. [Q60755-2]
DR   Ensembl; ENSMUST00000168592; ENSMUSP00000130243; ENSMUSG00000023964. [Q60755-2]
DR   Ensembl; ENSMUST00000170266; ENSMUSP00000132124; ENSMUSG00000023964. [Q60755-1]
DR   Ensembl; ENSMUST00000171613; ENSMUSP00000130083; ENSMUSG00000023964. [Q60755-2]
DR   GeneID; 12311; -.
DR   KEGG; mmu:12311; -.
DR   UCSC; uc009ave.1; mouse. [Q60755-2]
DR   UCSC; uc009avf.1; mouse. [Q60755-1]
DR   CTD; 799; -.
DR   MGI; MGI:101950; Calcr.
DR   VEuPathDB; HostDB:ENSMUSG00000023964; -.
DR   eggNOG; KOG4564; Eukaryota.
DR   GeneTree; ENSGT00940000155380; -.
DR   HOGENOM; CLU_002753_4_2_1; -.
DR   InParanoid; Q60755; -.
DR   OMA; CVAWILW; -.
DR   OrthoDB; 1005634at2759; -.
DR   PhylomeDB; Q60755; -.
DR   TreeFam; TF315710; -.
DR   Reactome; R-MMU-418555; G alpha (s) signalling events.
DR   Reactome; R-MMU-419812; Calcitonin-like ligand receptors.
DR   BioGRID-ORCS; 12311; 1 hit in 72 CRISPR screens.
DR   ChiTaRS; Calcr; mouse.
DR   PRO; PR:Q60755; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; Q60755; protein.
DR   Bgee; ENSMUSG00000023964; Expressed in arcuate nucleus of hypothalamus and 40 other tissues.
DR   Genevisible; Q60755; MM.
DR   GO; GO:0001669; C:acrosomal vesicle; IDA:MGI.
DR   GO; GO:0150056; C:amylin receptor complex 1; ISO:MGI.
DR   GO; GO:0150057; C:amylin receptor complex 2; ISO:MGI.
DR   GO; GO:0150058; C:amylin receptor complex 3; ISO:MGI.
DR   GO; GO:0030424; C:axon; ISO:MGI.
DR   GO; GO:0005929; C:cilium; IDA:MGI.
DR   GO; GO:0043005; C:neuron projection; ISO:MGI.
DR   GO; GO:0043025; C:neuronal cell body; ISO:MGI.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0097643; F:amylin receptor activity; ISO:MGI.
DR   GO; GO:0032841; F:calcitonin binding; ISO:MGI.
DR   GO; GO:0001635; F:calcitonin gene-related peptide receptor activity; ISO:MGI.
DR   GO; GO:0004948; F:calcitonin receptor activity; IDA:MGI.
DR   GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:MGI.
DR   GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; ISO:MGI.
DR   GO; GO:0097647; P:amylin receptor signaling pathway; ISO:MGI.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0038041; P:cross-receptor inhibition within G protein-coupled receptor heterodimer; ISO:MGI.
DR   GO; GO:0030279; P:negative regulation of ossification; IMP:MGI.
DR   GO; GO:0001503; P:ossification; IMP:MGI.
DR   GO; GO:0030316; P:osteoclast differentiation; IDA:MGI.
DR   GO; GO:0045762; P:positive regulation of adenylate cyclase activity; ISO:MGI.
DR   GO; GO:1905665; P:positive regulation of calcium ion import across plasma membrane; ISO:MGI.
DR   GO; GO:0010942; P:positive regulation of cell death; ISO:MGI.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:MGI.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:MGI.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
DR   GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISO:MGI.
DR   GO; GO:0010739; P:positive regulation of protein kinase A signaling; ISO:MGI.
DR   GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISO:MGI.
DR   GO; GO:0043488; P:regulation of mRNA stability; IDA:MGI.
DR   GO; GO:1904645; P:response to amyloid-beta; ISO:MGI.
DR   GO; GO:0051384; P:response to glucocorticoid; ISO:MGI.
DR   Gene3D; 4.10.1240.10; -; 1.
DR   InterPro; IPR003287; GCPR_2_calcitonin_rcpt_fam.
DR   InterPro; IPR017981; GPCR_2-like.
DR   InterPro; IPR001688; GPCR_2_calcitonin_rcpt.
DR   InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR   InterPro; IPR001879; GPCR_2_extracellular_dom.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR   PANTHER; PTHR45620:SF8; PTHR45620:SF8; 1.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF02793; HRM; 1.
DR   PRINTS; PR00361; CALCITONINR.
DR   PRINTS; PR01350; CTRFAMILY.
DR   PRINTS; PR00249; GPCRSECRETIN.
DR   SMART; SM00008; HormR; 1.
DR   SUPFAM; SSF111418; SSF111418; 1.
DR   PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1.
DR   PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR   PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell membrane; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..41
FT                   /evidence="ECO:0000255"
FT   CHAIN           42..533
FT                   /note="Calcitonin receptor"
FT                   /id="PRO_0000012807"
FT   TOPO_DOM        42..170
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..190
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        191..197
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..217
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..274
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..297
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        298..314
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..334
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        335..350
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        351..374
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        375..397
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        398..415
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        416..427
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        428..449
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        450..533
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        45
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        90
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        142
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        147
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        72..98
FT                   /evidence="ECO:0000250"
FT   DISULFID        89..129
FT                   /evidence="ECO:0000250"
FT   DISULFID        112..151
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         234..270
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_053294"
FT   CONFLICT        257
FT                   /note="S -> C (in Ref. 1; AAA69521)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        473
FT                   /note="Missing (in Ref. 1; AAA69521)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   533 AA;  62469 MW;  2598AF1EC7AA570B CRC64;
     MTPRRSRVKR RNLRKPKMRF LLVNRFTLLL LLLVSPTPVL QAPTNLTDSG LDQEPFLYLV
     GRKKLLDAQY KCYDRIHQLP SYEGEGLYCN RTWDGWMCWD DTPAGATAYQ HCPDYFPDFD
     TAEKVSKYCD ENGEWFRHPD SNRTWSNYTL CNAFTSEKLQ NAYVLYYLAL VGHSLSIAAL
     VASMLIFWIF KNLSCQRVTL HKHMFLTYIL NSIIIIIHLV EVVPNGDLVR RDPMHIFHHN
     THMWTMQWEL SPPLPLSAHE GKMDPHASEV ISCKVLHFLH QYMMSCNYFW MLCEGIYLHT
     LIVMAVFTDE QRLRWYYLLG WGFPIVPTII HAITRALYYN DNCWLSAETH LLYIIHGPVM
     VALVVNFFFL LNIVRVLVTK MRQTHEAESY MYLKAVKATM VLVPLLGIQF VVFPWRPSNK
     VLGKIYDYLM HSLIHFQGFF VATIYCFCNH EVQVTLKRQW TQFKIQWSQR WGRRRRPTNR
     VVSAPRAVAF AEPDGLPIYI CHQEPRNPPI SNNEGEESTE MIPMNVIQQD ASA
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024