ID   VKT_OXYMI               Reviewed;          17 AA.
AC   P0DJ63;
DT   16-NOV-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2011, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=Kunitz-type serine protease inhibitor OMI;
DE   Flags: Fragment;
OS   Oxyuranus microlepidotus (Inland taipan) (Diemenia microlepidota).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Acanthophiinae; Oxyuranus.
OX   NCBI_TaxID=111177;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=21843588; DOI=10.1016/j.biochi.2011.08.003;
RA   Earl S.T., Richards R., Johnson L.A., Flight S., Anderson S., Liao A.,
RA   de Jersey J., Masci P.P., Lavin M.F.;
RT   "Identification and characterisation of Kunitz-type plasma kallikrein
RT   inhibitors unique to Oxyuranus sp. snake venoms.";
RL   Biochimie 94:365-373(2012).
CC   -!- FUNCTION: Serine protease inhibitor that inhibits plasma kallikrein
CC       (Ki=1.7 nM), and plasmin (Ki=33.0 nM). {ECO:0000269|PubMed:21843588}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21843588}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:21843588}.
CC   -!- SIMILARITY: Belongs to the venom Kunitz-type family. {ECO:0000305}.
CC   -!- CAUTION: Attempts to clone the transcript coding for this protein
CC       failed. {ECO:0000305}.
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DR   AlphaFoldDB; P0DJ63; -.
DR   PRIDE; P0DJ63; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Protease inhibitor; Secreted;
KW   Serine protease inhibitor; Toxin.
FT   CHAIN           1..>17
FT                   /note="Kunitz-type serine protease inhibitor OMI"
FT                   /id="PRO_0000413846"
FT   DOMAIN          4..>17
FT                   /note="BPTI/Kunitz inhibitor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   SITE            14..15
FT                   /note="Reactive bond for trypsin"
FT                   /evidence="ECO:0000250"
FT   DISULFID        4..?
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   DISULFID        13..?
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT   NON_TER         17
SQ   SEQUENCE   17 AA;  1850 MW;  3315988A299DB1ED CRC64;
     KDFCHLPPKP GPCRAAI