ID   CALCR_PELRI             Reviewed;          37 AA.
AC   P31888;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Calcitonin gene-related peptide;
DE            Short=CGRP;
OS   Pelophylax ridibundus (Marsh frog) (Rana ridibunda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Pelophylax.
OX   NCBI_TaxID=8406;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT PHE-37.
RC   TISSUE=Brain, and Intestine;
RX   PubMed=8332553; DOI=10.1016/0196-9781(93)90148-a;
RA   Conlon J.M., Tonon M.-C., Vaudry H.;
RT   "Isolation and structural characterization of calcitonin gene-related
RT   peptide from the brain and intestine of the frog, Rana ridibunda.";
RL   Peptides 14:581-586(1993).
CC   -!- FUNCTION: CGRP induces vasodilation. It dilates a variety of vessels
CC       including the coronary, cerebral and systemic vasculature. Its
CC       abundance in the CNS also points toward a neurotransmitter or
CC       neuromodulator role.
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   AlphaFoldDB; P31888; -.
DR   SMR; P31888; -.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR018360; Calcitonin_CS.
DR   InterPro; IPR015476; Calcitonin_gene-rel_peptide.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   PANTHER; PTHR10505; PTHR10505; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00817; CALCITONINB.
DR   SMART; SM00113; CALCITONIN; 1.
DR   PROSITE; PS00258; CALCITONIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Hormone.
FT   PEPTIDE         1..37
FT                   /note="Calcitonin gene-related peptide"
FT                   /id="PRO_0000044674"
FT   MOD_RES         37
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:8332553"
FT   DISULFID        2..7
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   37 AA;  3887 MW;  0EFEE3AD2745EBDE CRC64;
     ACNTATCVTH RLADFLSRSG GMAKNNFVPT NVGSKAF