VL1_BPV6
ID VL1_BPV6 Reviewed; 138 AA.
AC P50807;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Major capsid protein L1;
DE Flags: Fragment;
GN Name=L1;
OS Bos taurus papillomavirus 6 (Bovine papillomavirus 6).
OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC Xipapillomavirus.
OX NCBI_TaxID=10563;
OH NCBI_TaxID=9913; Bos taurus (Bovine).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-95.
RX PubMed=7707535; DOI=10.1128/jvi.69.5.3074-3083.1995;
RA Chan S.-Y., Delius H., Halpern A.L., Bernard H.U.;
RT "Analysis of genomic sequences of 95 papillomavirus types: uniting typing,
RT phylogeny, and taxonomy.";
RL J. Virol. 69:3074-3083(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-138.
RX PubMed=1849970; DOI=10.1099/0022-1317-72-4-877;
RA Jackson M.E., Campo M.S.;
RT "Positive and negative E2-independent regulatory elements in the long
RT control region of bovine papillomavirus type 4.";
RL J. Gen. Virol. 72:877-883(1991).
CC -!- FUNCTION: Forms an icosahedral capsid with a T=7 symmetry and about 55
CC nm diameter. The capsid is composed of 72 pentamers linked to each
CC other by disulfide bonds and associated with L2 proteins. The capsid
CC encapsulates the genomic DNA, but does not bind DNA. Essential for the
CC initial attachment to the host cell (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Self-assembles into homopentamers. The capsid has an
CC icosahedral symmetry and consists of 72 capsomers, with each capsomer
CC being a pentamer of L1. Interacts with the minor capsid protein L2;
CC this interaction is necessary for viral genome encapsidation (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the papillomaviridae L1 protein family.
CC {ECO:0000305}.
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DR EMBL; U21864; AAA92827.1; -; Genomic_DNA.
DR EMBL; X59064; CAA41787.1; -; Genomic_DNA.
DR PIR; S15466; S15466.
DR SMR; P50807; -.
DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR Gene3D; 2.60.175.20; -; 2.
DR InterPro; IPR002210; Capsid_L1_Papillomavir.
DR InterPro; IPR036973; Capsid_L1_sf_Papillomavir.
DR InterPro; IPR011222; dsDNA_vir_gr_I_capsid.
DR Pfam; PF00500; Late_protein_L1; 1.
DR PRINTS; PR00865; HPVCAPSIDL1.
DR SUPFAM; SSF88648; SSF88648; 1.
PE 3: Inferred from homology;
KW Capsid protein; Host-virus interaction; Late protein;
KW Viral attachment to host cell; Virion; Virus entry into host cell.
FT CHAIN <1..138
FT /note="Major capsid protein L1"
FT /id="PRO_0000133480"
FT REGION 111..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 72..73
FT /note="AE -> CR (in Ref. 2; CAA41787)"
FT /evidence="ECO:0000305"
FT CONFLICT 86
FT /note="I -> V (in Ref. 2; CAA41787)"
FT /evidence="ECO:0000305"
FT CONFLICT 93..95
FT /note="SSN -> LLI (in Ref. 2; CAA41787)"
FT /evidence="ECO:0000305"
FT NON_TER 1
SQ SEQUENCE 138 AA; 16339 MW; E57FC72938053B70 CRC64;
YLRHVEEWEL SCIMQLCIVD LKPETLAHLH NMDPRILETW NLGFIQPPTN IEDQYRFIKS
LATKCPGKEE TAEKEDPYAK YKFWDINLTE RFSSNWNMYL GRNFLFQIGK RGSKRPAPKT
VTFDSSSKKA PKRRRKNA
