VL1_HPV09
ID VL1_HPV09 Reviewed; 507 AA.
AC Q02480;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 2.
DT 02-JUN-2021, entry version 98.
DE RecName: Full=Major capsid protein L1 {ECO:0000255|HAMAP-Rule:MF_04002};
GN Name=L1 {ECO:0000255|HAMAP-Rule:MF_04002};
OS Human papillomavirus 9.
OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC Betapapillomavirus.
OX NCBI_TaxID=10621;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8205838; DOI=10.1007/978-3-642-78487-3_2;
RA Delius H., Hofmann B.;
RT "Primer-directed sequencing of human papillomavirus types.";
RL Curr. Top. Microbiol. Immunol. 186:13-31(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 312-355.
RX PubMed=1326639; DOI=10.1128/jvi.66.10.5714-5725.1992;
RA Chan S.-Y., Bernard H.U., Ong C.K., Chan S.P., Birgit H., Delius H.;
RT "Phylogenetic analysis of 48 papillomavirus types and 28 subtypes and
RT variants: a showcase for the molecular evolution of DNA viruses.";
RL J. Virol. 66:5714-5725(1992).
CC -!- FUNCTION: Forms an icosahedral capsid with a T=7 symmetry and a 50 nm
CC diameter. The capsid is composed of 72 pentamers linked to each other
CC by disulfide bonds and associated with L2 proteins. Binds to heparan
CC sulfate proteoglycans on cell surface of basal layer keratinocytes to
CC provide initial virion attachment. This binding mediates a
CC conformational change in the virus capsid that facilitates efficient
CC infection. The virion enters the host cell via endocytosis. During
CC virus trafficking, L1 protein dissociates from the viral DNA and the
CC genomic DNA is released to the host nucleus. The virion assembly takes
CC place within the cell nucleus. Encapsulates the genomic DNA together
CC with protein L2. {ECO:0000255|HAMAP-Rule:MF_04002}.
CC -!- SUBUNIT: Self-assembles into homopentamers. The capsid has an
CC icosahedral symmetry and consists of 72 capsomers, with each capsomer
CC being a pentamer of L1. Interacts with the minor capsid protein L2;
CC this interaction is necessary for viral genome encapsidation. Interacts
CC with protein E2; this interaction enhances E2-dependent replication and
CC transcription activation. {ECO:0000255|HAMAP-Rule:MF_04002}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04002}. Host
CC nucleus {ECO:0000255|HAMAP-Rule:MF_04002}.
CC -!- SIMILARITY: Belongs to the papillomaviridae L1 protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04002}.
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DR EMBL; X74464; CAA52488.1; -; Genomic_DNA.
DR EMBL; M96301; AAA47040.1; -; Genomic_DNA.
DR PIR; S36595; S36595.
DR RefSeq; NP_041866.1; NC_001596.1.
DR SMR; Q02480; -.
DR DNASU; 1489482; -.
DR GeneID; 1489482; -.
DR KEGG; vg:1489482; -.
DR Proteomes; UP000009104; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0039620; C:T=7 icosahedral viral capsid; IEA:UniProtKB-UniRule.
DR GO; GO:0005198; F:structural molecule activity; IEA:UniProtKB-UniRule.
DR GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.175.20; -; 2.
DR HAMAP; MF_04002; PPV_L1; 1.
DR InterPro; IPR002210; Capsid_L1_Papillomavir.
DR InterPro; IPR036973; Capsid_L1_sf_Papillomavir.
DR InterPro; IPR011222; dsDNA_vir_gr_I_capsid.
DR Pfam; PF00500; Late_protein_L1; 1.
DR PRINTS; PR00865; HPVCAPSIDL1.
DR SUPFAM; SSF88648; SSF88648; 1.
PE 3: Inferred from homology;
KW Capsid protein; Disulfide bond; Host nucleus; Host-virus interaction;
KW Late protein; Reference proteome; T=7 icosahedral capsid protein;
KW Viral attachment to host cell; Viral penetration into host cytoplasm;
KW Virion; Virus endocytosis by host; Virus entry into host cell.
FT CHAIN 1..507
FT /note="Major capsid protein L1"
FT /id="PRO_0000133493"
FT DISULFID 175
FT /note="Interchain (with C-439)"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04002"
FT DISULFID 439
FT /note="Interchain (with C-175)"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04002"
SQ SEQUENCE 507 AA; 57492 MW; 9BCA3AD3F031A62F CRC64;
MSLWLPASGK VYLPPATPVA RVQSTDEYVE RTNIFYHAIS DRLLTVGHPY YDVRSGDGQR
IEVPKVSGNQ YRAFRISLPD PNRFALADMS VYNPDKERLV WACRGIEIGR GQPLGVGTSG
HPLFNKVRDT ENSSNYQGTT MDDRQNTSFD PKQVQMFIIG CIPCLGEHWD KAKVCEKDAN
NQLGLCPPIE LRNTVIEDGD MFDIGFGNIN NKELSFNKSD VSLDIVDETC KYPDFLTMAN
DVYGDACFFF ARREQCYARH YYVRGGSVGD AVPDGAVNQD HNFFLPAKSD QQQRTIANST
YYPTVSGSLV TSDAQLFNRP FWLQRAQGHN NGILWGNQIF VTVADNTRNT NFTISVSTEA
AQTEEYNANN IREYLRHVEE YQISLILQLC KVPLVAEVLS QINAMNSGIL EDWQLGFVPT
PENAVHDIYR YIDSKATKCP DAVEPTEKED PFAKYSFWKV DLTERLSLDL DQYPLGRKFL
FQAGLQTRKR PIKTSVKTSK NAKRRRT