VL1_HPV13
ID VL1_HPV13 Reviewed; 499 AA.
AC Q02273; Q90075;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1993, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Major capsid protein L1 {ECO:0000255|HAMAP-Rule:MF_04002};
GN Name=L1 {ECO:0000255|HAMAP-Rule:MF_04002};
OS Human papillomavirus 13.
OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC Alphapapillomavirus.
OX NCBI_TaxID=10573;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1325697; DOI=10.1016/0042-6822(92)90896-w;
RA van Ranst M., Fuse A., Fiten P., Beuken E., Pfister H., Burk R.D.,
RA Opdenakker G.;
RT "Human papillomavirus type 13 and pygmy chimpanzee papillomavirus type 1:
RT comparison of the genome organizations.";
RL Virology 190:587-596(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 331-364.
RX PubMed=1321168; DOI=10.1128/jcm.30.7.1716-1721.1992;
RA van den Brule A.J., Snijders P.J., Raaphorst P.M., Schrijnemakers H.F.,
RA Delius H., Gissmann L., Meijer C.J., Walboomers J.M.;
RT "General primer polymerase chain reaction in combination with sequence
RT analysis for identification of potentially novel human papillomavirus
RT genotypes in cervical lesions.";
RL J. Clin. Microbiol. 30:1716-1721(1992).
CC -!- FUNCTION: Forms an icosahedral capsid with a T=7 symmetry and a 50 nm
CC diameter. The capsid is composed of 72 pentamers linked to each other
CC by disulfide bonds and associated with L2 proteins. Binds to heparan
CC sulfate proteoglycans on cell surface of basal layer keratinocytes to
CC provide initial virion attachment. This binding mediates a
CC conformational change in the virus capsid that facilitates efficient
CC infection. The virion enters the host cell via endocytosis. During
CC virus trafficking, L1 protein dissociates from the viral DNA and the
CC genomic DNA is released to the host nucleus. The virion assembly takes
CC place within the cell nucleus. Encapsulates the genomic DNA together
CC with protein L2. {ECO:0000255|HAMAP-Rule:MF_04002}.
CC -!- SUBUNIT: Self-assembles into homopentamers. The capsid has an
CC icosahedral symmetry and consists of 72 capsomers, with each capsomer
CC being a pentamer of L1. Interacts with the minor capsid protein L2;
CC this interaction is necessary for viral genome encapsidation. Interacts
CC with protein E2; this interaction enhances E2-dependent replication and
CC transcription activation. {ECO:0000255|HAMAP-Rule:MF_04002}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04002}. Host
CC nucleus {ECO:0000255|HAMAP-Rule:MF_04002}.
CC -!- SIMILARITY: Belongs to the papillomaviridae L1 protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04002}.
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DR EMBL; X62843; CAA44654.1; -; Genomic_DNA.
DR EMBL; S40235; AAB22562.1; -; Genomic_DNA.
DR PIR; H42955; P1WL13.
DR SMR; Q02273; -.
DR Proteomes; UP000009107; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0039620; C:T=7 icosahedral viral capsid; IEA:UniProtKB-UniRule.
DR GO; GO:0005198; F:structural molecule activity; IEA:UniProtKB-UniRule.
DR GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.175.20; -; 2.
DR HAMAP; MF_04002; PPV_L1; 1.
DR InterPro; IPR002210; Capsid_L1_Papillomavir.
DR InterPro; IPR036973; Capsid_L1_sf_Papillomavir.
DR InterPro; IPR011222; dsDNA_vir_gr_I_capsid.
DR Pfam; PF00500; Late_protein_L1; 1.
DR PRINTS; PR00865; HPVCAPSIDL1.
DR SUPFAM; SSF88648; SSF88648; 1.
PE 3: Inferred from homology;
KW Capsid protein; Disulfide bond; Host nucleus; Host-virus interaction;
KW Late protein; T=7 icosahedral capsid protein;
KW Viral attachment to host cell; Viral penetration into host cytoplasm;
KW Virion; Virus endocytosis by host; Virus entry into host cell.
FT CHAIN 1..499
FT /note="Major capsid protein L1"
FT /id="PRO_0000133497"
FT REGION 472..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 172
FT /note="Interchain (with C-423)"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04002"
FT DISULFID 423
FT /note="Interchain (with C-172)"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04002"
SQ SEQUENCE 499 AA; 55773 MW; AA6D5F7FFFD24759 CRC64;
MWRPSDNKLY VPPPAPVSKV ITTDAYVTRT NIFYHASSSR LLAVGNPYFP IKKQNKTVVP
KVSGYQFRVF KVVLPDPNKF ALPDTSIFDS TSQRLVWACT GLEVGRGQPL GVGISGHPLL
NKYDDVENSA SYAANPGQDN RVNVAMDYKQ TQLCLVGCAP PLGEHWGQGK QCTGVNVQPG
DCPPLELISS VIQDGDMVDT GFGAMNFAEL QSNKSDVPLD ICTSTCKYPD YLQMAADPYG
DRLFFYLRKE QMFARHFFNR AGSVGEQIPA ELYVKGSNTL SNSIYYNTPS GSLVSSEAQL
FNKPYWLQKA QGHNNGICWG NHLFVTVVDT TRSTNMTVCA ATTSSLSDTY KATEYKQYMR
HVEEFDLQFI FQLCTIKLTA EVMSYIHTMN PTILEDWNFG LSPPPNGTLE DTYRYVQSQA
ITCQKPTPDK EKQDPYAGLS FWEVNLKEKF SSELDQYPLG RKFLLQTGVQ SRSPIRVGRK
RAASTSTATP TTRKKAKRK