VL1_HPV41
ID VL1_HPV41 Reviewed; 534 AA.
AC P27557;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 2.
DT 23-FEB-2022, entry version 94.
DE RecName: Full=Major capsid protein L1 {ECO:0000255|HAMAP-Rule:MF_04002};
GN Name=L1 {ECO:0000255|HAMAP-Rule:MF_04002};
OS Human papillomavirus type 41.
OC Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC Nupapillomavirus.
OX NCBI_TaxID=10589;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1645904; DOI=10.1016/0168-1702(91)90017-p;
RA Hirt L., Hirsch-Behnam A., de Villiers E.M.;
RT "Nucleotide sequence of human papillomavirus (HPV) type 41: an unusual HPV
RT type without a typical E2 binding site consensus sequence.";
RL Virus Res. 18:179-190(1991).
CC -!- FUNCTION: Forms an icosahedral capsid with a T=7 symmetry and a 50 nm
CC diameter. The capsid is composed of 72 pentamers linked to each other
CC by disulfide bonds and associated with L2 proteins. Binds to heparan
CC sulfate proteoglycans on cell surface of basal layer keratinocytes to
CC provide initial virion attachment. This binding mediates a
CC conformational change in the virus capsid that facilitates efficient
CC infection. The virion enters the host cell via endocytosis. During
CC virus trafficking, L1 protein dissociates from the viral DNA and the
CC genomic DNA is released to the host nucleus. The virion assembly takes
CC place within the cell nucleus. Encapsulates the genomic DNA together
CC with protein L2. {ECO:0000255|HAMAP-Rule:MF_04002}.
CC -!- SUBUNIT: Self-assembles into homopentamers. The capsid has an
CC icosahedral symmetry and consists of 72 capsomers, with each capsomer
CC being a pentamer of L1. Interacts with the minor capsid protein L2;
CC this interaction is necessary for viral genome encapsidation. Interacts
CC with protein E2; this interaction enhances E2-dependent replication and
CC transcription activation. {ECO:0000255|HAMAP-Rule:MF_04002}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04002}. Host
CC nucleus {ECO:0000255|HAMAP-Rule:MF_04002}.
CC -!- SIMILARITY: Belongs to the papillomaviridae L1 protein family.
CC {ECO:0000255|HAMAP-Rule:MF_04002}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA39619.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X56147; CAA39619.1; ALT_INIT; Genomic_DNA.
DR PIR; H43550; P1WL41.
DR RefSeq; NP_040294.1; NC_001354.1.
DR SMR; P27557; -.
DR PRIDE; P27557; -.
DR GeneID; 1489283; -.
DR KEGG; vg:1489283; -.
DR Proteomes; UP000006367; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0039620; C:T=7 icosahedral viral capsid; IEA:UniProtKB-UniRule.
DR GO; GO:0005198; F:structural molecule activity; IEA:UniProtKB-UniRule.
DR GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.175.20; -; 2.
DR HAMAP; MF_04002; PPV_L1; 1.
DR InterPro; IPR002210; Capsid_L1_Papillomavir.
DR InterPro; IPR036973; Capsid_L1_sf_Papillomavir.
DR InterPro; IPR011222; dsDNA_vir_gr_I_capsid.
DR Pfam; PF00500; Late_protein_L1; 1.
DR PRINTS; PR00865; HPVCAPSIDL1.
DR SUPFAM; SSF88648; SSF88648; 1.
PE 3: Inferred from homology;
KW Capsid protein; Disulfide bond; Host nucleus; Host-virus interaction;
KW Late protein; Reference proteome; T=7 icosahedral capsid protein;
KW Viral attachment to host cell; Viral penetration into host cytoplasm;
KW Virion; Virus endocytosis by host; Virus entry into host cell.
FT CHAIN 1..534
FT /note="Major capsid protein L1"
FT /id="PRO_0000133525"
FT REGION 507..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 200
FT /note="Interchain (with C-459)"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04002"
FT DISULFID 459
FT /note="Interchain (with C-200)"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04002"
SQ SEQUENCE 534 AA; 60950 MW; 61B0E3EA4181511B CRC64;
MIYILACCAG NVKNANVFIF QMAVWLPGPN RFYLPPQPIQ RTLNTEEYVR RTSTFLHAAT
DRLLTVGHPF YNITNADGKE VVPKVSSNQF RAFRVRFPNP NTFAFCDKSL FNPDKERLVW
GIRGIEVSRG QPLGIGVTGN PFFNKFDDAE NPYNGINKNN ITDQGSDSRL SIAFDPKQTQ
LLIVGAKPAK GEYWDVAATC ENPPLTKADD KCPALELKSS YIEDADMSDI GLGNLNFSTL
QRNKSDAPLD IVDSICKYPD YLQMIEELYG DHMFFYVRRE ALYARHIMQH AGKMDAEQFP
TSLYIDSSVE GEKLNSLQRT DRYFMTPSGS LVATEQQLFN RPFWLQRSQG HNNGILWHNE
AFVTLVDTTR GTNFTISVPE GDASSYNNSK FFEFLRHTEE FQLAFILQLC KVDLTPENLA
YIHTMDPSII EDWHLAVTSP PNSVLEDHYR YILSIATKCP SKDADDTSTD PYKDLKFWEV
DLRDRMTEQL DQTPLGRKFL FQTGITQSSS NKRVSTQSTA LTTYRRPTKR RRKA
