ID   CALC_BOVIN              Reviewed;          32 AA.
AC   P01260;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Calcitonin;
GN   Name=CALCA; Synonyms=CALC;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT PRO-32.
RX   PubMed=5259773; DOI=10.1073/pnas.63.3.940;
RA   Brewer H.B. Jr., Ronan R.;
RT   "Amino acid sequence of bovine thyrocalcitonin.";
RL   Proc. Natl. Acad. Sci. U.S.A. 63:940-947(1969).
CC   -!- FUNCTION: Causes a rapid but short-lived drop in the level of calcium
CC       and phosphate in blood by promoting the incorporation of those ions in
CC       the bones.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   PIR; A38048; TCBO.
DR   AlphaFoldDB; P01260; -.
DR   SMR; P01260; -.
DR   STRING; 9913.ENSBTAP00000053947; -.
DR   MetOSite; P01260; -.
DR   PaxDb; P01260; -.
DR   PRIDE; P01260; -.
DR   eggNOG; ENOG502RZI5; Eukaryota.
DR   HOGENOM; CLU_122444_0_0_1; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR021118; Calcitonin.
DR   InterPro; IPR018360; Calcitonin_CS.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   PRINTS; PR00270; CALCITONINA.
DR   SMART; SM00113; CALCITONIN; 1.
DR   PROSITE; PS00258; CALCITONIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Hormone;
KW   Reference proteome; Secreted.
FT   PEPTIDE         1..32
FT                   /note="Calcitonin"
FT                   /id="PRO_0000044665"
FT   MOD_RES         32
FT                   /note="Proline amide"
FT                   /evidence="ECO:0000269|PubMed:5259773"
FT   DISULFID        1..7
FT                   /evidence="ECO:0000269|PubMed:5259773"
SQ   SEQUENCE   32 AA;  3596 MW;  EDEA2A3ADFFE4909 CRC64;
     CSNLSTCVLS AYWKDLNNYH RFSGMGFGPE TP