ID   VL1_HPV50               Reviewed;         515 AA.
AC   P50818; Q80933;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   23-FEB-2022, entry version 81.
DE   RecName: Full=Major capsid protein L1 {ECO:0000255|HAMAP-Rule:MF_04002};
GN   Name=L1 {ECO:0000255|HAMAP-Rule:MF_04002};
OS   Human papillomavirus type 50.
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC   Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC   Gammapapillomavirus.
OX   NCBI_TaxID=40539;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Delius H.;
RL   Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 380-475.
RX   PubMed=7707535; DOI=10.1128/jvi.69.5.3074-3083.1995;
RA   Chan S.-Y., Delius H., Halpern A.L., Bernard H.U.;
RT   "Analysis of genomic sequences of 95 papillomavirus types: uniting typing,
RT   phylogeny, and taxonomy.";
RL   J. Virol. 69:3074-3083(1995).
CC   -!- FUNCTION: Forms an icosahedral capsid with a T=7 symmetry and a 50 nm
CC       diameter. The capsid is composed of 72 pentamers linked to each other
CC       by disulfide bonds and associated with L2 proteins. Binds to heparan
CC       sulfate proteoglycans on cell surface of basal layer keratinocytes to
CC       provide initial virion attachment. This binding mediates a
CC       conformational change in the virus capsid that facilitates efficient
CC       infection. The virion enters the host cell via endocytosis. During
CC       virus trafficking, L1 protein dissociates from the viral DNA and the
CC       genomic DNA is released to the host nucleus. The virion assembly takes
CC       place within the cell nucleus. Encapsulates the genomic DNA together
CC       with protein L2. {ECO:0000255|HAMAP-Rule:MF_04002}.
CC   -!- SUBUNIT: Self-assembles into homopentamers. The capsid has an
CC       icosahedral symmetry and consists of 72 capsomers, with each capsomer
CC       being a pentamer of L1. Interacts with the minor capsid protein L2;
CC       this interaction is necessary for viral genome encapsidation. Interacts
CC       with protein E2; this interaction enhances E2-dependent replication and
CC       transcription activation. {ECO:0000255|HAMAP-Rule:MF_04002}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04002}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04002}.
CC   -!- SIMILARITY: Belongs to the papillomaviridae L1 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04002}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U31790; AAA79477.1; -; Genomic_DNA.
DR   EMBL; U21870; AAA92832.1; -; Genomic_DNA.
DR   RefSeq; NP_043429.1; NC_001691.1.
DR   SMR; P50818; -.
DR   GeneID; 1403635; -.
DR   KEGG; vg:1403635; -.
DR   Proteomes; UP000168289; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039620; C:T=7 icosahedral viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0005198; F:structural molecule activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.175.20; -; 2.
DR   HAMAP; MF_04002; PPV_L1; 1.
DR   InterPro; IPR002210; Capsid_L1_Papillomavir.
DR   InterPro; IPR036973; Capsid_L1_sf_Papillomavir.
DR   InterPro; IPR011222; dsDNA_vir_gr_I_capsid.
DR   Pfam; PF00500; Late_protein_L1; 1.
DR   PRINTS; PR00865; HPVCAPSIDL1.
DR   SUPFAM; SSF88648; SSF88648; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Disulfide bond; Host nucleus; Host-virus interaction;
KW   Late protein; Reference proteome; T=7 icosahedral capsid protein;
KW   Viral attachment to host cell; Viral penetration into host cytoplasm;
KW   Virion; Virus endocytosis by host; Virus entry into host cell.
FT   CHAIN           1..515
FT                   /note="Major capsid protein L1"
FT                   /id="PRO_0000133533"
FT   DISULFID        174
FT                   /note="Interchain (with C-445)"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04002"
FT   DISULFID        445
FT                   /note="Interchain (with C-174)"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04002"
SQ   SEQUENCE   515 AA;  58426 MW;  0D79EA3A1A215BC0 CRC64;
     MAHWSSTSGK LYLPPSTPVA RVLSTDEYVK ETDVYFHARS ERLLIVGHPY YDIEDGGDIK
     VPKVSANQYR VFRCELPDPN KFALIDTTLY NSDTERLVWK LVGIEVGRGG PLGVGSTGHP
     LFNKVGDTEN PSFYLGPQEK DERQNLSIDP KQTQLLIVGC KPAVGEYWDL AEPCDKNSLN
     NGKCPPIQLV NSYIQDGDMG DIGFGNANFP KLQQDRAGVP LDIVDSISLW PDLLKMTKDV
     YGDHVFFYAK QEQLYARHLF THAGPIGEPI PNVSGVYNYA VNPNQPEQNR RTNIGSYLYF
     TTPSGSLNTS SSQLFNRPYW IRRAQGTNNC ICWGNEVFVT VFDNTRNINF NISVKKDVNP
     LDPLNVASSY MYSKDDFNQY SRHTEEYELE FIFQLCKVGL DADILAHLNV MDPRILENWQ
     LAYVPPAPSG IGDTYRYLKS DATKCPAKDS SAEVVDPYKE YTFWNVNLTE KFSSELDQYA
     LGRKFLFQTG LLKRRVRTDY TVATVSKPNK RKRTR