ID   VL1_HPV63               Reviewed;         507 AA.
AC   Q07861;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   23-FEB-2022, entry version 93.
DE   RecName: Full=Major capsid protein L1 {ECO:0000255|HAMAP-Rule:MF_04002};
GN   Name=L1 {ECO:0000255|HAMAP-Rule:MF_04002};
OS   Human papillomavirus type 63.
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC   Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC   Mupapillomavirus.
OX   NCBI_TaxID=28311;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8389082; DOI=10.1006/viro.1993.1320;
RA   Egawa K., Delius H., Matsukura T., Kawashima M., de Villiers E.M.;
RT   "Two novel types of human papillomavirus, HPV 63 and HPV 65: comparisons of
RT   their clinical and histological features and DNA sequences to other HPV
RT   types.";
RL   Virology 194:789-799(1993).
CC   -!- FUNCTION: Forms an icosahedral capsid with a T=7 symmetry and a 50 nm
CC       diameter. The capsid is composed of 72 pentamers linked to each other
CC       by disulfide bonds and associated with L2 proteins. Binds to heparan
CC       sulfate proteoglycans on cell surface of basal layer keratinocytes to
CC       provide initial virion attachment. This binding mediates a
CC       conformational change in the virus capsid that facilitates efficient
CC       infection. The virion enters the host cell via endocytosis. During
CC       virus trafficking, L1 protein dissociates from the viral DNA and the
CC       genomic DNA is released to the host nucleus. The virion assembly takes
CC       place within the cell nucleus. Encapsulates the genomic DNA together
CC       with protein L2. {ECO:0000255|HAMAP-Rule:MF_04002}.
CC   -!- SUBUNIT: Self-assembles into homopentamers. The capsid has an
CC       icosahedral symmetry and consists of 72 capsomers, with each capsomer
CC       being a pentamer of L1. Interacts with the minor capsid protein L2;
CC       this interaction is necessary for viral genome encapsidation. Interacts
CC       with protein E2; this interaction enhances E2-dependent replication and
CC       transcription activation. {ECO:0000255|HAMAP-Rule:MF_04002}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04002}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04002}.
CC   -!- SIMILARITY: Belongs to the papillomaviridae L1 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04002}.
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DR   EMBL; X70828; CAA50170.1; -; Genomic_DNA.
DR   RefSeq; NP_040902.1; NC_001458.1.
DR   SMR; Q07861; -.
DR   GeneID; 1494575; -.
DR   KEGG; vg:1494575; -.
DR   Proteomes; UP000007671; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039620; C:T=7 icosahedral viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0005198; F:structural molecule activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.175.20; -; 1.
DR   HAMAP; MF_04002; PPV_L1; 1.
DR   InterPro; IPR002210; Capsid_L1_Papillomavir.
DR   InterPro; IPR036973; Capsid_L1_sf_Papillomavir.
DR   InterPro; IPR011222; dsDNA_vir_gr_I_capsid.
DR   Pfam; PF00500; Late_protein_L1; 1.
DR   PRINTS; PR00865; HPVCAPSIDL1.
DR   SUPFAM; SSF88648; SSF88648; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Disulfide bond; Host nucleus; Host-virus interaction;
KW   Late protein; Reference proteome; T=7 icosahedral capsid protein;
KW   Viral attachment to host cell; Viral penetration into host cytoplasm;
KW   Virion; Virus endocytosis by host; Virus entry into host cell.
FT   CHAIN           1..507
FT                   /note="Major capsid protein L1"
FT                   /id="PRO_0000133545"
FT   DISULFID        176
FT                   /note="Interchain (with C-433)"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04002"
FT   DISULFID        433
FT                   /note="Interchain (with C-176)"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04002"
SQ   SEQUENCE   507 AA;  57555 MW;  4466333C9C9403A9 CRC64;
     MAVWLPAQNK FYLPTQPITK ILSSDDYVSR TNIFYHATSD RLLIVGHPLY EVTRANDNTM
     TVPKVSPNQY RVFRVRFPDP NRFAFGDKDI FDPETERLVW GLRGIEIGRG QPLGVGISGN
     PLLNRFDDAE NPSRYNNTHA TGDNRQNVAF DAKQTQMFLI GCTPATGEHW SIARRCAGTQ
     FQLGDCPPIE LVNTVIEDGD MFDIGLGAMD FGSLQANKAD APLDIAGTVC KYPDYIKMGQ
     EVHGNSLFFF ARREQMYLRH VFTHAGIVSE KEKVPTSAYI AAKAEQPQNT IATDNYFVAP
     SGSLVSSDVQ IFNRPYWLQR SQGQNNGICW RNELFVTVAD NTRGTTMNIN VLNKATPETY
     DSADYNEYTR HVEEYELSFI VQLCKVKLTP ENLAFLHNMD PTIIDSWQLT VSQPPANAIE
     DKYRFIESLA TKCPDNVPPP TPTDPYKDLR FWDVDLSERM SEQLDQFPLG RKFLYQSGLA
     QRSVPKTVNF RKRRSSNTTV AKRRRRA