ID   VL1_HPV64               Reviewed;         153 AA.
AC   P50824;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   12-AUG-2020, entry version 66.
DE   RecName: Full=Major capsid protein L1;
DE   Flags: Fragment;
GN   Name=L1;
OS   Human papillomavirus type 64.
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC   Zurhausenvirales; Papillomaviridae; unclassified Papillomaviridae.
OX   NCBI_TaxID=37118;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7963696; DOI=10.1093/infdis/170.5.1077;
RA   Bernard H.U., Chan S.-Y., Manos M.M., Ong C.K., Villa L.L., Delius H.,
RA   Peyton C.L., Bauer H.M., Wheeler C.M.;
RT   "Identification and assessment of known and novel human papillomaviruses by
RT   polymerase chain reaction amplification, restriction fragment length
RT   polymorphisms, nucleotide sequence, and phylogenetic algorithms.";
RL   J. Infect. Dis. 170:1077-1085(1994).
CC   -!- FUNCTION: Forms an icosahedral capsid with a T=7 symmetry and about 55
CC       nm diameter. The capsid is composed of 72 pentamers linked to each
CC       other by disulfide bonds and associated with L2 proteins. The capsid
CC       encapsulates the genomic DNA, but does not bind DNA. Essential for the
CC       initial attachment to the host cell (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Self-assembles into homopentamers. The capsid has an
CC       icosahedral symmetry and consists of 72 capsomers, with each capsomer
CC       being a pentamer of L1. Interacts with the minor capsid protein L2;
CC       this interaction is necessary for viral genome encapsidation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the papillomaviridae L1 protein family.
CC       {ECO:0000305}.
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DR   EMBL; U12495; AAA67239.1; -; Genomic_DNA.
DR   GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.175.20; -; 2.
DR   InterPro; IPR002210; Capsid_L1_Papillomavir.
DR   InterPro; IPR036973; Capsid_L1_sf_Papillomavir.
DR   InterPro; IPR011222; dsDNA_vir_gr_I_capsid.
DR   Pfam; PF00500; Late_protein_L1; 1.
DR   PRINTS; PR00865; HPVCAPSIDL1.
DR   SUPFAM; SSF88648; SSF88648; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Host-virus interaction; Late protein;
KW   Viral attachment to host cell; Virion; Virus entry into host cell.
FT   CHAIN           <1..>153
FT                   /note="Major capsid protein L1"
FT                   /id="PRO_0000133546"
FT   NON_TER         1
FT   NON_TER         153
SQ   SEQUENCE   153 AA;  17658 MW;  E881598CADCF02F1 CRC64;
     AQGHNNGICW HNQLFLTVVY TTRSTNFSVC VGTQSTSTNP PYANTNFKEY LRHAEEYDLE
     FVFQLCKITL TTDVMTYIHS MSSSILEQWN FGLTPPPSGT LEETYRYVTS QAITCQRPQP
     PKESEDPYAK MTFWEVDLKE KFSAELDQFP FGR