ID   VL1_OVPVD               Reviewed;         513 AA.
AC   P03104;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Major capsid protein L1 {ECO:0000255|HAMAP-Rule:MF_04002};
GN   Name=L1 {ECO:0000255|HAMAP-Rule:MF_04002};
OS   Odocoileus virginianus papillomavirus 1 (DPV) (Deer papillomavirus).
OC   Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes;
OC   Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae;
OC   Deltapapillomavirus.
OX   NCBI_TaxID=2772504;
OH   NCBI_TaxID=9874; Odocoileus virginianus (White-tailed deer).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2993669; DOI=10.1128/jvi.56.1.85-91.1985;
RA   Groff D.E., Lancaster W.D.;
RT   "Molecular cloning and nucleotide sequence of deer papillomavirus.";
RL   J. Virol. 56:85-91(1985).
CC   -!- FUNCTION: Forms an icosahedral capsid with a T=7 symmetry and a 50 nm
CC       diameter. The capsid is composed of 72 pentamers linked to each other
CC       by disulfide bonds and associated with L2 proteins. Binds to heparan
CC       sulfate proteoglycans on cell surface of basal layer keratinocytes to
CC       provide initial virion attachment. This binding mediates a
CC       conformational change in the virus capsid that facilitates efficient
CC       infection. The virion enters the host cell via endocytosis. During
CC       virus trafficking, L1 protein dissociates from the viral DNA and the
CC       genomic DNA is released to the host nucleus. The virion assembly takes
CC       place within the cell nucleus. Encapsulates the genomic DNA together
CC       with protein L2. {ECO:0000255|HAMAP-Rule:MF_04002}.
CC   -!- SUBUNIT: Self-assembles into homopentamers. The capsid has an
CC       icosahedral symmetry and consists of 72 capsomers, with each capsomer
CC       being a pentamer of L1. Interacts with the minor capsid protein L2;
CC       this interaction is necessary for viral genome encapsidation. Interacts
CC       with protein E2; this interaction enhances E2-dependent replication and
CC       transcription activation. {ECO:0000255|HAMAP-Rule:MF_04002}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04002}. Host
CC       nucleus {ECO:0000255|HAMAP-Rule:MF_04002}.
CC   -!- SIMILARITY: Belongs to the papillomaviridae L1 protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04002}.
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DR   EMBL; M11910; AAA66848.1; -; Genomic_DNA.
DR   PIR; A03645; P1WLDP.
DR   RefSeq; NP_041300.1; NC_001523.1.
DR   SMR; P03104; -.
DR   GeneID; 1488986; -.
DR   KEGG; vg:1488986; -.
DR   Proteomes; UP000009185; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0039620; C:T=7 icosahedral viral capsid; IEA:UniProtKB-UniRule.
DR   GO; GO:0005198; F:structural molecule activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.175.20; -; 1.
DR   HAMAP; MF_04002; PPV_L1; 1.
DR   InterPro; IPR002210; Capsid_L1_Papillomavir.
DR   InterPro; IPR036973; Capsid_L1_sf_Papillomavir.
DR   InterPro; IPR011222; dsDNA_vir_gr_I_capsid.
DR   Pfam; PF00500; Late_protein_L1; 1.
DR   PRINTS; PR00865; HPVCAPSIDL1.
DR   SUPFAM; SSF88648; SSF88648; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Disulfide bond; Host nucleus; Host-virus interaction;
KW   Late protein; Reference proteome; T=7 icosahedral capsid protein;
KW   Viral attachment to host cell; Viral penetration into host cytoplasm;
KW   Virion; Virus endocytosis by host; Virus entry into host cell.
FT   CHAIN           1..513
FT                   /note="Major capsid protein L1"
FT                   /id="PRO_0000133557"
FT   DISULFID        172
FT                   /note="Interchain (with C-426)"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04002"
FT   DISULFID        426
FT                   /note="Interchain (with C-172)"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04002"
SQ   SEQUENCE   513 AA;  58145 MW;  40CC5EAF4446015A CRC64;
     MAFWQPGQAL YLPPTPVTKV LCSEQYINVR DIFYHGETER MLTSGSILSL EVTQKHTTVP
     KVSPNQYRVF RVALPDPNQF ALPDKALHNP SKERLVWAVV GVQVSRGQPL GGEVRGHSYF
     NTFLDAENVS KKVTAQGTDD RKQAGMDTKQ QQVLMLGCTP AIGEYWTKAR PCVTDRPDAG
     SCPPIELKLS FIEDGDMMDI GFGAANFKEL NATKSDLPLD IANSICLYPD YLKMTEEAAG
     NSMFFFARKE QVYVRHIWTP WGTDKELPPE AYYLKPPGEM ELKMPSVFFA SPSGSLVSTD
     GQLFNRPYWI LRAQGMNNGV CWNNTLFVTV GDNTRGSTLT ITVPNNDEPL TEYDTSKFNV
     YQRHVEEFKL AFILELCSVE LTPETVSSLQ GSMPSILENW EINLQPPTSS VLEDIYRFID
     SPATKCADNV SPSKPEDPYS AHKFWEVNLK EKLSLDLDQF PLGRLVLQFD CRLDRLLPQK
     DHFTYPEKRY KRHMRITGTV RKVLLYICFS LNS