ID   CALC_CHICK              Reviewed;         138 AA.
AC   P07660;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 2.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Calcitonin;
DE   Flags: Precursor;
GN   Name=CALCA; Synonyms=CALC;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3666142; DOI=10.1016/0014-5793(87)80510-0;
RA   Minvielle S., Cressent M., Delehaye M.C., Segond N., Milhaud G.,
RA   Jullienne A., Moukhtar M.S., Lasmoles F.;
RT   "Sequence and expression of the chicken calcitonin gene.";
RL   FEBS Lett. 223:63-68(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 12-138.
RX   PubMed=4054101; DOI=10.1002/j.1460-2075.1985.tb03977.x;
RA   Lasmoles F., Jullienne A., Day F., Minvielle S., Milhaud G., Moukhtar M.S.;
RT   "Elucidation of the nucleotide sequence of chicken calcitonin mRNA: direct
RT   evidence for the expression of a lower vertebrate calcitonin-like gene in
RT   man and rat.";
RL   EMBO J. 4:2603-2607(1985).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 71-117.
RX   PubMed=3838160; DOI=10.1016/0014-5793(85)80242-8;
RA   Lasmoles F., Jullienne A., Desplan C., Milhaud G., Moukhtar M.S.;
RT   "Structure of chicken calcitonin predicted by partial nucleotide sequence
RT   of its precursor.";
RL   FEBS Lett. 180:113-116(1985).
RN   [4]
RP   NUCLEOTIDE SEQUENCE OF 82-113.
RX   PubMed=3782060; DOI=10.1093/oxfordjournals.jbchem.a121734;
RA   Homma T., Watanabe M., Hirose S., Kanai A., Kangawa K., Matsuo H.;
RT   "Isolation and determination of the amino acid sequence of chicken
RT   calcitonin I from chicken ultimobranchial glands.";
RL   J. Biochem. 100:459-467(1986).
CC   -!- FUNCTION: Causes a rapid but short-lived drop in the level of calcium
CC       and phosphate in blood by promoting the incorporation of those ions in
CC       the bones.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Calcitonin;
CC         IsoId=P07660-1; Sequence=Displayed;
CC       Name=Calcitonin-gene related peptide;
CC         IsoId=P10286-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   EMBL; X06311; CAA29630.1; -; Genomic_DNA.
DR   EMBL; X06312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; X06313; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; X03012; CAA26796.1; -; mRNA.
DR   EMBL; M27563; AAA48648.1; -; mRNA.
DR   PIR; S00153; TCCH.
DR   AlphaFoldDB; P07660; -.
DR   SMR; P07660; -.
DR   STRING; 9031.ENSGALP00000009748; -.
DR   PaxDb; P07660; -.
DR   VEuPathDB; HostDB:geneid_396256; -.
DR   eggNOG; ENOG502RZI5; Eukaryota.
DR   InParanoid; P07660; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR021118; Calcitonin.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR018360; Calcitonin_CS.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   PANTHER; PTHR10505; PTHR10505; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00270; CALCITONINA.
DR   SMART; SM00113; CALCITONIN; 1.
DR   PROSITE; PS00258; CALCITONIN; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW   Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..79
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000004071"
FT   PEPTIDE         82..113
FT                   /note="Calcitonin"
FT                   /evidence="ECO:0000269|PubMed:3782060"
FT                   /id="PRO_0000004072"
FT   PROPEP          118..138
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000004073"
FT   MOD_RES         113
FT                   /note="Proline amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        82..88
FT   CONFLICT        56
FT                   /note="D -> E (in Ref. 2; CAA26796)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   138 AA;  15308 MW;  730B618CF724F248 CRC64;
     MVMLKISSFL AVYALVVCQM DSFQAAPVRP GLESITDRVT LSDYEARRLL NALVKDFIQM
     TAEELEQASE GNSLDRPISK RCASLSTCVL GKLSQELHKL QTYPRTDVGA GTPGKKRNVL
     NDLDHERYAN YGETLGNN