ID   CALC_HORSE              Reviewed;         140 AA.
AC   Q9N0V5;
DT   10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Calcitonin;
DE   Flags: Precursor;
GN   Name=CALCA; Synonyms=CALC;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Thyroid;
RX   PubMed=12581884; DOI=10.1016/s0303-7207(02)00289-7;
RA   Toribio R.E., Kohn C.W., Leone G.W., Capen C.C., Rosol T.J.;
RT   "Molecular cloning and expression of equine calcitonin, calcitonin gene-
RT   related peptide-I, and calcitonin gene-related peptide-II.";
RL   Mol. Cell. Endocrinol. 199:119-128(2003).
CC   -!- FUNCTION: Causes a rapid but short-lived drop in the level of calcium
CC       and phosphate in blood by promoting the incorporation of those ions in
CC       the bones. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Calcitonin;
CC         IsoId=Q9N0V5-1; Sequence=Displayed;
CC       Name=Calcitonin-gene related peptide I;
CC         IsoId=Q9N0T2-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   EMBL; AF249307; AAF72526.1; -; mRNA.
DR   RefSeq; NP_001075323.1; NM_001081854.3. [Q9N0V5-1]
DR   RefSeq; XP_014596965.1; XM_014741479.1. [Q9N0V5-1]
DR   AlphaFoldDB; Q9N0V5; -.
DR   PaxDb; Q9N0V5; -.
DR   Ensembl; ENSECAT00000008055; ENSECAP00000005990; ENSECAG00000007825. [Q9N0V5-1]
DR   GeneID; 100033906; -.
DR   KEGG; ecb:100033906; -.
DR   CTD; 796; -.
DR   GeneTree; ENSGT00940000156267; -.
DR   HOGENOM; CLU_122444_0_0_1; -.
DR   InParanoid; Q9N0V5; -.
DR   OMA; KKRDMAN; -.
DR   TreeFam; TF333069; -.
DR   Proteomes; UP000002281; Chromosome 7.
DR   Bgee; ENSECAG00000007825; Expressed in testis and 9 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031716; F:calcitonin receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   InterPro; IPR021118; Calcitonin.
DR   InterPro; IPR021117; Calcitonin-like.
DR   InterPro; IPR021116; Calcitonin/adrenomedullin.
DR   InterPro; IPR018360; Calcitonin_CS.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   PANTHER; PTHR10505; PTHR10505; 1.
DR   Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR   PRINTS; PR00270; CALCITONINA.
DR   SMART; SM00113; CALCITONIN; 1.
DR   PROSITE; PS00258; CALCITONIN; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW   Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PROPEP          26..81
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000004044"
FT   PEPTIDE         84..115
FT                   /note="Calcitonin"
FT                   /id="PRO_0000004045"
FT   PROPEP          120..140
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000004046"
FT   MOD_RES         115
FT                   /note="Proline amide"
FT                   /evidence="ECO:0000250"
FT   DISULFID        84..90
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   140 AA;  15358 MW;  8ACCC4015AF3DEB7 CRC64;
     MGFWKFSPFL PLSILVLYQV GIIQAAPFRS ALESLPDPAV LPEEESRLLL AALVKDYVQM
     KVRALEQEQE TGGASLDSPR AKRCSNLSTC VLGTYTQDLN KFHTFPQTAI GVGAPGKKRV
     MARGLERDHG PHIGTSQDAY